MiR-21 is under control of STAT5 but is dispensable for mammary development and lactation.
PLoS One
; 9(1): e85123, 2014.
Article
em En
| MEDLINE
| ID: mdl-24497923
ABSTRACT
Development of mammary alveolar epithelium during pregnancy is controlled by prolactin, through the transcription factors STAT5A/B that activate specific sets of target genes. Here we asked whether some of STAT5's functions are mediated by microRNAs. The miR-21 promoter sequence contains a bona-fide STAT5 binding site and miR-21 levels increased in HC11 mammary cells upon prolactin treatment. In vivo miR-21 was abundantly expressed in mammary epithelium at day 6 of pregnancy. Analysis of mice lacking miR-21 revealed that their mammary tissue developed normally during pregnancy and dams were able to nurse their pups. Our study demonstrated that although expression of miR-21 is under prolactin control through the transcription factors STAT5A/B its presence is dispensable for mammary development and lactation.
Texto completo:
1
Bases de dados:
MEDLINE
Assunto principal:
Lactação
/
MicroRNAs
/
Fator de Transcrição STAT5
/
Glândulas Mamárias Animais
Limite:
Animals
/
Pregnancy
Idioma:
En
Revista:
PLoS One
Assunto da revista:
CIENCIA
/
MEDICINA
Ano de publicação:
2014
Tipo de documento:
Article
País de afiliação:
Estados Unidos