Network dynamics in the tumor microenvironment.
Semin Cancer Biol
; 30: 52-9, 2015 Feb.
Article
em En
| MEDLINE
| ID: mdl-24582766
ABSTRACT
The evolutionary path from tumor initiation to metastasis can only be fully understood by considering cancer cells as part of a multi-species ecosystem within the tumor microenvironment. This paper reviews and suggests two important recent trends. Firstly, I review arguments that interactions among diverse cells in the tumor microenvironment create a distinct cellular environment that can confer growth advantages, resist interventions, and allow tumors to remain dormant for long periods. Second, I review and highlight a trend toward data-rich, molecularly detailed, computational models of the tumor microenvironment. I argue that data-driven molecularly detailed tumor microenvironment models can now be built using data from multiple emerging high-throughput technologies, and that such models can pinpoint mechanisms of dysregulation and suggest specific drug targets and follow up experiments.
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Texto completo:
1
Bases de dados:
MEDLINE
Assunto principal:
Modelos Moleculares
/
Biologia de Sistemas
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Microambiente Tumoral
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Neoplasias
Limite:
Humans
Idioma:
En
Revista:
Semin Cancer Biol
Assunto da revista:
NEOPLASIAS
Ano de publicação:
2015
Tipo de documento:
Article