A mathematical model of intrahost pneumococcal pneumonia infection dynamics in murine strains.
J Theor Biol
; 353: 44-54, 2014 Jul 21.
Article
em En
| MEDLINE
| ID: mdl-24594373
ABSTRACT
The seriousness of pneumococcal pneumonia in mouse models has been shown to depend both on bacterial serotype and murine strain. We here present a simple ordinary differential equation model of the intrahost immune response to bacterial pneumonia that is capable of capturing diverse experimentally determined responses of various murine strains. We discuss the main causes of such differences while accounting for the uncertainty in the estimation of model parameters. We model the bacterial population in both the lungs and blood, the cellular death caused by the infection, and the activation and immigration of phagocytes to the infected tissue. The ensemble model suggests that inter-strain differences in response to streptococcus pneumonia inoculation reside in the strength of nonspecific immune response and the rate of extrapulmonary phagocytosis.
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Texto completo:
1
Bases de dados:
MEDLINE
Assunto principal:
Pneumonia Pneumocócica
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Streptococcus pneumoniae
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Interações Hospedeiro-Patógeno
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Modelos Biológicos
Tipo de estudo:
Prognostic_studies
Limite:
Animals
Idioma:
En
Revista:
J Theor Biol
Ano de publicação:
2014
Tipo de documento:
Article