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Estimating telomere length from whole genome sequence data.
Ding, Zhihao; Mangino, Massimo; Aviv, Abraham; Spector, Tim; Durbin, Richard.
Afiliação
  • Ding Z; Genome Informatics, Wellcome Trust Sanger Institute, Hinxton, CB10 1SA, UK.
  • Mangino M; Department of Twin Research and Genetic Epidemiology, King's College London, London, WC2R 2LS, UK.
  • Aviv A; The Center for Human Development and Aging, New Jersey Medical School, Rutgers University, Newark, NJ 07103, USA.
  • Spector T; Department of Twin Research and Genetic Epidemiology, King's College London, London, WC2R 2LS, UK.
  • Durbin R; Genome Informatics, Wellcome Trust Sanger Institute, Hinxton, CB10 1SA, UK rd@sanger.ac.uk.
Nucleic Acids Res ; 42(9): e75, 2014 May.
Article em En | MEDLINE | ID: mdl-24609383
ABSTRACT
Telomeres play a key role in replicative ageing and undergo age-dependent attrition in vivo. Here, we report a novel method, TelSeq, to measure average telomere length from whole genome or exome shotgun sequence data. In 260 leukocyte samples, we show that TelSeq results correlate with Southern blot measurements of the mean length of terminal restriction fragments (mTRFs) and display age-dependent attrition comparably well as mTRFs.
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Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Telômero / Análise de Sequência de DNA Tipo de estudo: Observational_studies / Prevalence_studies / Risk_factors_studies Limite: Adult / Aged / Humans / Middle aged Idioma: En Revista: Nucleic Acids Res Ano de publicação: 2014 Tipo de documento: Article País de afiliação: Reino Unido
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Telômero / Análise de Sequência de DNA Tipo de estudo: Observational_studies / Prevalence_studies / Risk_factors_studies Limite: Adult / Aged / Humans / Middle aged Idioma: En Revista: Nucleic Acids Res Ano de publicação: 2014 Tipo de documento: Article País de afiliação: Reino Unido