Factors affecting the nuclear localization of ß-catenin in normal and malignant tissue.
J Cell Biochem
; 115(8): 1351-61, 2014 Aug.
Article
em En
| MEDLINE
| ID: mdl-24610469
ABSTRACT
The canonical Wnt signaling pathway has been the focus of intensive research because of its frequent dysregulation in human cancers. Much of this has been directed towards the aberrant expression and/or activity of the central mediator of this pathway, ß-catenin. In particular, the nuclear localization of ß-catenin and subsequent inappropriate activation of TCF/LEF-mediated transcription appears to be an important process in both the establishment and maintenance of cancer stem cells. Despite this, the exact mechanisms controlling ß-catenin nuclear localization in both normal and malignant cells are poorly understood. This prospect article brings together the many mechanisms previously reported to regulate the nuclear localization of ß-catenin and how they are relevant to cancer.
Palavras-chave
Texto completo:
1
Bases de dados:
MEDLINE
Assunto principal:
Transcrição Gênica
/
Beta Catenina
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Via de Sinalização Wnt
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Neoplasias
Limite:
Humans
Idioma:
En
Revista:
J Cell Biochem
Ano de publicação:
2014
Tipo de documento:
Article
País de afiliação:
Reino Unido