Association between 1019C/T polymorphism in the connexin 37 gene and essential hypertension.
Heart Lung Circ
; 23(10): 924-9, 2014 Oct.
Article
em En
| MEDLINE
| ID: mdl-24685073
ABSTRACT
OBJECTIVE:
To investigate the association between the CX 37 1019C/T polymorphism and the susceptibility to essential hypertension (EH).METHODS:
A total of 1126 cases of EH were diagnosed in the People's Hospital of Wuxi City, China. A control group consisted of 874 healthy people, i.e., non-EH patients. All cases were genotyped by DNA sequencing.RESULTS:
Polymorphism C1019T on the Connexin37 gene was found in the whole population. The distribution of three genotype frequencies in both groups was in accordance with the Hardy-Weinberg equilibrium. The frequency of the CX37C allele was higher in EH patients (57.4% vs. 42.1%, χ(2)=92.5, P<0.01) compared to the control group. The frequency of C carriers (CC+TC) was 80.5% in EH patients compared to 66.7% in the control (χ(2)=49.0, P<0.01). EH risk was significantly increased in carriers of C the allele (CC+TC) over that in the TT homozygote (OR=2.06, 95% CI 1.68 â¼ 2.52). Subsequent stratified analyses demonstrate that a significant difference exists in the frequency of C carriers between male EH patients and controls (79.2% vs. 69.1%, χ(2)=13.4, P<0.01) and in female EH patients and the control group (81.8% vs. 64.4%, χ(2)=38.7, P<0.01). The carriers of the C allele had higher EH risk compared with the TT homozygote without sex differences (male OR=1.71, 95% CI 1.28 â¼ 2.27; female OR=2.48, 95%CI 1.85 â¼ 3.31).CONCLUSION:
The C allele in the CX37 gene might be associated with the susceptibility to EH in population of Wuxi, China.Palavras-chave
Texto completo:
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Bases de dados:
MEDLINE
Assunto principal:
Conexinas
/
Hipertensão
Tipo de estudo:
Observational_studies
/
Risk_factors_studies
Limite:
Aged
/
Aged80
/
Female
/
Humans
/
Male
/
Middle aged
País/Região como assunto:
Asia
Idioma:
En
Revista:
Heart Lung Circ
Assunto da revista:
ANGIOLOGIA
/
CARDIOLOGIA
Ano de publicação:
2014
Tipo de documento:
Article