[Medullary carcinoma of the breast. Co-expression of keratin intermediate filaments and protein S-100 in tumor cells]. / Carcinoma midollare della mammella. Coespressione dei filamenti intermedi di cheratine e della proteina S-100 nelle cellule tumorali.
Pathologica
; 81(1074): 433-9, 1989.
Article
em It
| MEDLINE
| ID: mdl-2483260
ABSTRACT
We have chosen 10 medullary carcinomas from a retrospective investigation on 450 cases of breast carcinoma (2.2%), according to the histomorphological criteria of Ridolfi and colleagues. By immunoperoxidase staining, we have evaluated the distribution of keratin and vimentin intermediate filaments, of CEA and S-100 protein in cancer cells. A widespread positivity to keratins has been proved in 70% of medullary carcinomas. Numerous neoplastic cells have coexpressed S-100 protein. We hypothesize the epithelial and myoepithelial "intermediate" differentiation of keratin and S-100 protein positive tumour cells.
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Bases de dados:
MEDLINE
Assunto principal:
Vimentina
/
Citoesqueleto
/
Filamentos Intermediários
/
Neoplasias da Mama
/
Carcinoma
/
Antígeno Carcinoembrionário
/
Proteínas S100
/
Queratinas
Limite:
Adult
/
Aged
/
Aged80
/
Female
/
Humans
/
Middle aged
Idioma:
It
Revista:
Pathologica
Ano de publicação:
1989
Tipo de documento:
Article