Disrupting information coding via block of 4-AP-sensitive potassium channels.
J Neurophysiol
; 112(5): 1054-66, 2014 Sep 01.
Article
em En
| MEDLINE
| ID: mdl-24899672
ABSTRACT
Recent interest has emerged on the role of intrinsic biophysical diversity in neuronal coding. An important question in neurophysiology is understanding which voltage-gated ion channels are responsible for this diversity and how variable expression or activity of one class of ion channels across neurons of a single type affects they way populations carry information. In mitral cells in the olfactory bulb of mice, we found that biophysical diversity was conferred in part by 4-aminopyridine (4-AP)-sensitive potassium channels and reduced following block of those channels. When populations of mitral cells were stimulated with identical inputs, the diversity exhibited in their output spike patterns reduced with the addition of 4-AP, decreasing the stimulus information carried by ensembles of 15 neurons from 437 ± 15 to 397 ± 19 bits/s. Decreases in information were due to reduction in the diversity of population spike patterns generated in response to different features of the stimulus, suggesting that the coding capacity of a population can be altered by changes in the function of single ion channel types.
Palavras-chave
Texto completo:
1
Bases de dados:
MEDLINE
Assunto principal:
Bulbo Olfatório
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Potenciais de Ação
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4-Aminopiridina
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Canais de Potássio de Abertura Dependente da Tensão da Membrana
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Bloqueadores dos Canais de Potássio
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Neurônios
Tipo de estudo:
Diagnostic_studies
Limite:
Animals
Idioma:
En
Revista:
J Neurophysiol
Ano de publicação:
2014
Tipo de documento:
Article