Discovery and in Vivo Evaluation of Potent Dual CYP11B2 (Aldosterone Synthase) and CYP11B1 Inhibitors.

Meredith, Erik L; Ksander, Gary; Monovich, Lauren G; Papillon, Julien P N; Liu, Qian; Miranda, Karl; Morris, Patrick; Rao, Chang; Burgis, Robin; Capparelli, Michael; Hu, Qi-Ying; Singh, Alok; Rigel, Dean F; Jeng, Arco Y; Beil, Michael; Fu, Fumin; Hu, Chii-Whei; LaSala, Daniel

Meredith, Erik L; Ksander, Gary; Monovich, Lauren G; Papillon, Julien P N; Liu, Qian; Miranda, Karl; Morris, Patrick; Rao, Chang; Burgis, Robin; Capparelli, Michael; Hu, Qi-Ying; Singh, Alok; Rigel, Dean F; Jeng, Arco Y; Beil, Michael; Fu, Fumin; Hu, Chii-Whei; LaSala, Daniel.

Afiliação

Meredith EL; Novartis Institutes for BioMedical Research , 100 Technology Square, Cambridge, Massachusetts 02139, United States.
Ksander G; Novartis Institutes for BioMedical Research , 100 Technology Square, Cambridge, Massachusetts 02139, United States.
Monovich LG; Novartis Institutes for BioMedical Research , 100 Technology Square, Cambridge, Massachusetts 02139, United States.
Papillon JP; Novartis Institutes for BioMedical Research , 100 Technology Square, Cambridge, Massachusetts 02139, United States.
Liu Q; Novartis Institutes for BioMedical Research , 100 Technology Square, Cambridge, Massachusetts 02139, United States.
Miranda K; Novartis Institutes for BioMedical Research , 100 Technology Square, Cambridge, Massachusetts 02139, United States.
Morris P; Novartis Institutes for BioMedical Research , 100 Technology Square, Cambridge, Massachusetts 02139, United States.
Rao C; Novartis Institutes for BioMedical Research , 100 Technology Square, Cambridge, Massachusetts 02139, United States.
Burgis R; Novartis Institutes for BioMedical Research , 100 Technology Square, Cambridge, Massachusetts 02139, United States.
Capparelli M; Novartis Institutes for BioMedical Research , 100 Technology Square, Cambridge, Massachusetts 02139, United States.
Hu QY; Novartis Institutes for BioMedical Research , 100 Technology Square, Cambridge, Massachusetts 02139, United States.
Singh A; Novartis Institutes for BioMedical Research , 100 Technology Square, Cambridge, Massachusetts 02139, United States.
Rigel DF; Novartis Pharmaceuticals Corporation , East Hanover, New Jersey 07936, United States.
Jeng AY; Novartis Pharmaceuticals Corporation , East Hanover, New Jersey 07936, United States.
Beil M; Novartis Pharmaceuticals Corporation , East Hanover, New Jersey 07936, United States.
Fu F; Novartis Pharmaceuticals Corporation , East Hanover, New Jersey 07936, United States.
Hu CW; Novartis Pharmaceuticals Corporation , East Hanover, New Jersey 07936, United States.
LaSala D; Novartis Pharmaceuticals Corporation , East Hanover, New Jersey 07936, United States.

ACS Med Chem Lett ; 4(12): 1203-7, 2013 Dec 12.

Article em En | MEDLINE | ID: mdl-24900631

Palavras-chave

CYP11B1; CYP11B2; Cushing's syndrome; Inhibitor; aldosterone; aldosterone synthase; cortisol; enzyme; hypertension

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Texto completo: 1 Bases de dados: MEDLINE Idioma: En Revista: ACS Med Chem Lett Ano de publicação: 2013 Tipo de documento: Article País de afiliação: Estados Unidos