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CD27(+)CD56Bright natural killer cells may be involved in spontaneous clearance of acute hepatitis C in HIV-positive patients.

Eisenhardt, Marianne; Glässner, Andreas; Wolter, Franziska; Krämer, Benjamin; Kokordelis, Pavlos; Nischalke, Hans-Dieter; Boesecke, Christoph; Rockstroh, Jürgen K; Spengler, Ulrich; Nattermann, Jacob.
AIDS ; 28(13): 1879-84, 2014 Aug 24.
Artigo em Inglês | MEDLINE | ID: mdl-24922598

OBJECTIVE:

The objective of this study was to analyse the potential role of CD27 in natural killer (NK) cell-mediated control of hepatitis C virus (HCV) infection in HIV-positive patients.

DESIGN:

Frequency of CD27-expressing CD56 NK cells was analysed in HIV mono-infected individuals and HIV-positive patients with acute or chronic hepatitis C. Anti-HCV activity of CD27(+) and CD27(-) NK cells was compared.

METHODS:

NK cell mediated inhibition of HCV replication was analysed using the HUH7 HCV Replicon model. NK cell phenotype and interferon (IFN) secretion was studied by flowcytometry.

RESULTS:

High frequency of CD27(+)CD56 NK cells is associated with spontaneous clearance of acute hepatitis C in HIV-positive patients. Accordingly, we found CD27(+)CD56 NK cells to display strong anti-HCV activity.

CONCLUSION:

Our results underline the important role of NK cells in modulating outcome of HCV infection.