Development of an in vitro liquid chromatography-mass spectrometry method to evaluate stereo and chemical stability of new drug candidates employing immobilized artificial membrane column.

Cannazza, Giuseppe; Battisti, Umberto M; Carrozzo, Marina M; Cazzato, Addolorata S; Braghiroli, Daniela; Parenti, Carlo; Troisi, Luigino

Cannazza, Giuseppe; Battisti, Umberto M; Carrozzo, Marina M; Cazzato, Addolorata S; Braghiroli, Daniela; Parenti, Carlo; Troisi, Luigino.

Afiliação

Cannazza G; Department of Life Sciences, University of Modena & Reggio Emilia, Via Campi 183, 41125 Modena, Italy. Electronic address: giuseppe.cannazza@unimore.it.
Battisti UM; Department of Life Sciences, University of Modena & Reggio Emilia, Via Campi 183, 41125 Modena, Italy.
Carrozzo MM; Department of Biological and Environmental Sciences and Technologies, University of Salento, via Prov.le Lecce-Monteroni, 73100 Lecce, Italy.
Cazzato AS; Department of Life Sciences, University of Modena & Reggio Emilia, Via Campi 183, 41125 Modena, Italy.
Braghiroli D; Department of Life Sciences, University of Modena & Reggio Emilia, Via Campi 183, 41125 Modena, Italy.
Parenti C; Department of Life Sciences, University of Modena & Reggio Emilia, Via Campi 183, 41125 Modena, Italy.
Troisi L; Department of Biological and Environmental Sciences and Technologies, University of Salento, via Prov.le Lecce-Monteroni, 73100 Lecce, Italy.

J Chromatogr A ; 1363: 216-25, 2014 Oct 10.

Article em En | MEDLINE | ID: mdl-24935265

Assuntos

Cromatografia Líquida/métodos; Espectrometria de Massas/métodos; Membranas Artificiais; Cromatografia Líquida de Alta Pressão/métodos; Hidrólise; Técnicas In Vitro; Cinética; Fosfolipídeos/química; Solventes; Estereoisomerismo

Palavras-chave

Benzothiadiazines; Chiral OD column; Hydrolysis; IAM column; Racemization

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Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Espectrometria de Massas / Cromatografia Líquida / Membranas Artificiais Idioma: En Revista: J Chromatogr A Ano de publicação: 2014 Tipo de documento: Article

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