Interplay between the temporal dynamics of the vaginal microbiota and human papillomavirus detection.
J Infect Dis
; 210(11): 1723-33, 2014 Dec 01.
Article
em En
| MEDLINE
| ID: mdl-24943724
ABSTRACT
BACKGROUND:
We sought to describe the temporal relationship between vaginal microbiota and human papillomavirus (HPV) detection.METHODS:
Thirty-two reproductive-age women self-collected midvaginal swabs twice weekly for 16 weeks (937 samples). Vaginal bacterial communities were characterized by pyrosequencing of barcoded 16S rRNA genes and clustered into 6 community state types (CSTs). Each swab was tested for 37 HPV types. The effects of CSTs on the rate of transition between HPV-negative and HPV-positive states were assessed using continuous-time Markov models.RESULTS:
Participants had an average of 29 samples, with HPV point prevalence between 58%-77%. CST was associated with changes in HPV status (P<.001). Lactobacillus gasseri-dominated CSTs had the fastest HPV remission rate, and a low Lactobacillus community with high proportions of the genera Atopobium (CST IV-B) had the slowest rate compared to L. crispatus-dominated CSTs (adjusted transition rate ratio [aTRR], 4.43, 95% confidence interval [CI], 1.11-17.7; aTRR, 0.33, 95% CI, .12-1.19, respectively). The rate ratio of incident HPV for low Lactobacillus CST IV-A was 1.86 (95% CI, .52-6.74).CONCLUSIONS:
Vaginal microbiota dominated by L. gasseri was associated with increased clearance of detectable HPV. Frequent longitudinal sampling is necessary for evaluation of the association between HPV detection and dynamic microbiota.Palavras-chave
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Bases de dados:
MEDLINE
Assunto principal:
Vagina
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Infecções por Papillomavirus
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Alphapapillomavirus
Tipo de estudo:
Diagnostic_studies
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Etiology_studies
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Health_economic_evaluation
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Prognostic_studies
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Risk_factors_studies
Limite:
Adolescent
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Adult
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Female
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Humans
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Middle aged
Idioma:
En
Revista:
J Infect Dis
Ano de publicação:
2014
Tipo de documento:
Article