Micafungin at physiological serum concentrations shows antifungal activity against Candida albicans and Candida parapsilosis biofilms.
Antimicrob Agents Chemother
; 58(9): 5581-4, 2014 Sep.
Article
em En
| MEDLINE
| ID: mdl-24957821
We assessed the in vitro activity of micafungin against preformed Candida biofilms by measuring the concentration of drug causing the most fungal damage and inhibition of regrowth. We studied 37 biofilm-producing Candida spp. strains from blood cultures. We showed that micafungin was active against planktonic and sessile forms of Candida albicans strains and moderately active against Candida parapsilosis sessile cells. Concentrations of micafungin above 2 µg/ml were sufficiently high to inactivate regrowth of Candida sessile cells.
Texto completo:
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Bases de dados:
MEDLINE
Assunto principal:
Candida albicans
/
Biofilmes
/
Equinocandinas
/
Lipopeptídeos
/
Antifúngicos
Limite:
Humans
Idioma:
En
Revista:
Antimicrob Agents Chemother
Ano de publicação:
2014
Tipo de documento:
Article