Maternal hypertriglyceridemia: A link between maternal overweight-obesity and macrosomia in gestational diabetes.
Obesity (Silver Spring)
; 22(10): 2156-63, 2014 Oct.
Article
em En
| MEDLINE
| ID: mdl-24957884
ABSTRACT
OBJECTIVE:
Infants born from overweight and obese mothers with glucose-controlled gestational diabetes (GDM) tend to be large-for-gestational age (LGA). It is hypothesized that this is due to an excessive rise in maternal triglyceride levels.METHODS:
Two-hundred and seventy nine singleton GDM pregnancies were divided into three groups according to prepregnancy BMI normal weight (BMI = 20-24.9; n = 128), overweight (BMI = 25-29.9; n = 105), and obese (BMI ≥ 30; n = 46). Individual z-scores (ZS) of maternal triglycerides and of newborn weight (NWZS) were calculated as deviations from published 50th percentiles. Mean z-scores (MZS) were the average of triglyceride ZSs. MZS of triglycerides, HbA1c and NWZS were compared. Variables are expressed as mean ± SD.RESULTS:
In the three groups respectively LGA (%) = 10.1%, 19.0% and 30.4% (P = 0.015). Birth weight (g) = 3274.2 ± 501.3, 3342.4 ± 620.2 and 3366.3±644.7 (RSPEARMAN = 0.111, P = 0.027). HbA1c (%) = 5.2 ± 0.39, 5.3 ± 0.50 and 5.4 ± 0.47 (P = NS). Triglyceride MZS = 1.20 ± 1.13, 1.52 ± 1.37 and 1.62 ± 1.42 (RSPEARMAN = 0.116, P = 0.024). Correlations between triglyceride MZS and NWZS were, respectively r = 0.12 (P = NS), r = 0.42 (P <0.001), and r = 0.47 (P < 0.001).CONCLUSIONS:
In overweight and obese GDM mothers, maternal triglycerides are partially responsible for LGA infants despite good maternal glucose control during pregnancy.
Texto completo:
1
Bases de dados:
MEDLINE
Assunto principal:
Complicações na Gravidez
/
Macrossomia Fetal
/
Hipertrigliceridemia
/
Diabetes Gestacional
/
Obesidade
Tipo de estudo:
Observational_studies
/
Risk_factors_studies
Limite:
Adult
/
Female
/
Humans
/
Newborn
/
Pregnancy
Idioma:
En
Revista:
Obesity (Silver Spring)
Assunto da revista:
CIENCIAS DA NUTRICAO
/
FISIOLOGIA
/
METABOLISMO
Ano de publicação:
2014
Tipo de documento:
Article
País de afiliação:
Chile