Dok1 and Dok2 proteins regulate natural killer cell development and function.
EMBO J
; 33(17): 1928-40, 2014 Sep 01.
Article
em En
| MEDLINE
| ID: mdl-24963146
ABSTRACT
Natural killer (NK) cells are involved in immune responses against tumors and microbes. NK-cell activation is regulated by intrinsic and extrinsic mechanisms that ensure NK tolerance and efficacy. Here, we show that the cytoplasmic signaling molecules Dok1 and Dok2 are tyrosine phosphorylated upon NK-cell activation. Overexpression of Dok proteins in human NK cells reduces cell activation induced by NK-cell-activating receptors. Dok1 and Dok2 gene ablation in mice induces an NK-cell maturation defect and leads to increased IFN-γ production induced by activating receptors. Taken together, these results reveal that Dok1 and Dok2 proteins are involved in an intrinsic negative feedback loop downstream of NK-cell-activating receptors in mouse and human.
Palavras-chave
Texto completo:
1
Bases de dados:
MEDLINE
Assunto principal:
Fosfoproteínas
/
Células Matadoras Naturais
/
Ativação Linfocitária
/
Proteínas de Ligação a RNA
/
Proteínas Adaptadoras de Transdução de Sinal
/
Proteínas de Ligação a DNA
Limite:
Animals
/
Humans
Idioma:
En
Revista:
EMBO J
Ano de publicação:
2014
Tipo de documento:
Article
País de afiliação:
França