Laboratory animal models to study foot-and-mouth disease: a review with emphasis on natural and vaccine-induced immunity.
J Gen Virol
; 95(Pt 11): 2329-2345, 2014 Nov.
Article
em En
| MEDLINE
| ID: mdl-25000962
ABSTRACT
Laboratory animal models have provided valuable insight into foot-and-mouth disease virus (FMDV) pathogenesis in epidemiologically important target species. While not perfect, these models have delivered an accelerated time frame to characterize the immune responses in natural hosts and a platform to evaluate therapeutics and vaccine candidates at a reduced cost. Further expansion of these models in mice has allowed access to genetic mutations not available for target species, providing a powerful and versatile experimental system to interrogate the immune response to FMDV and to target more expensive studies in natural hosts. The purpose of this review is to describe commonly used FMDV infection models in laboratory animals and to cite examples of when these models have failed or successfully provided insight relevant for target species, with an emphasis on natural and vaccine-induced immunity.
Texto completo:
1
Bases de dados:
MEDLINE
Assunto principal:
Vacinas Virais
/
Vírus da Febre Aftosa
/
Febre Aftosa
Limite:
Animals
Idioma:
En
Revista:
J Gen Virol
Ano de publicação:
2014
Tipo de documento:
Article
País de afiliação:
Reino Unido