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Low antibody-dependent cellular cytotoxicity responses in Zambians prior to HIV-1 intrasubtype C superinfection.
Basu, Debby; Xiao, Peng; Ende, Zachary; Bere, Alfred; Britt, William J; Mulenga, Joseph; Kilembe, William; Allen, Susan A; Derdeyn, Cynthia A; Hunter, Eric.
Afiliação
  • Basu D; Emory Vaccine Center at Yerkes National Primate Research Center, 954 Gatewood Road, Atlanta, GA 30329, USA. Electronic address: dbasu@emory.edu.
  • Xiao P; Emory Vaccine Center at Yerkes National Primate Research Center, 954 Gatewood Road, Atlanta, GA 30329, USA. Electronic address: peng.xiao@emory.edu.
  • Ende Z; Emory Vaccine Center at Yerkes National Primate Research Center, 954 Gatewood Road, Atlanta, GA 30329, USA. Electronic address: zachary.s.ende@emory.edu.
  • Bere A; Emory Vaccine Center at Yerkes National Primate Research Center, 954 Gatewood Road, Atlanta, GA 30329, USA. Electronic address: alfred.bere@emory.edu.
  • Britt WJ; University of Alabama - Birmingham, 1600 7th Avenue South, Children׳s Harbor Building 107, Birmingham, AL 35233-1711, USA. Electronic address: WBritt@peds.uab.edu.
  • Mulenga J; Zambia Emory HIV Research Project (ZEHRP), B22/737 Mwembelelo, Emmasdale, Post Net 412; P/BagE891, Zambia. Electronic address: joseph.mulenga@znbts.gov.zm.
  • Kilembe W; Zambia Emory HIV Research Project (ZEHRP), B22/737 Mwembelelo, Emmasdale, Post Net 412; P/BagE891, Zambia. Electronic address: wkilembe@rzhrg-mail.org.
  • Allen SA; Zambia Emory HIV Research Project (ZEHRP), B22/737 Mwembelelo, Emmasdale, Post Net 412; P/BagE891, Zambia; Department of Global Health, Rollins School of Public Health, Emory University, 1518 Clifton Rd NE, Atlanta, GA 30322, USA; Department of Pathology and Laboratory Medicine, Emory University, 10
  • Derdeyn CA; Emory Vaccine Center at Yerkes National Primate Research Center, 954 Gatewood Road, Atlanta, GA 30329, USA; Department of Pathology and Laboratory Medicine, Emory University, 101, Woodruff Circle, Atlanta, GA 30322, USA. Electronic address: cderdey@emory.edu.
  • Hunter E; Emory Vaccine Center at Yerkes National Primate Research Center, 954 Gatewood Road, Atlanta, GA 30329, USA; Department of Pathology and Laboratory Medicine, Emory University, 101, Woodruff Circle, Atlanta, GA 30322, USA. Electronic address: ehunte4@emory.edu.
Virology ; 462-463: 295-8, 2014 Aug.
Article em En | MEDLINE | ID: mdl-25004405
We have previously shown that HIV-1 superinfected Zambian seroconverters mount low binding and neutralizing antibody responses to their primary HIV-1 infecting virus, which could increase susceptibility to re-infection. Here, we investigated if antibody-dependent cellular cytotoxicity (ADCC), a process by which virus-infected cells are killed, was also reduced. Superinfected individuals exhibited low ADCC activity compared to non-superinfected individuals, but similar levels of CMV-reactive binding antibodies, suggesting superinfected individuals are capable of generating and maintaining virus-specific antibodies.
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Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Anticorpos Anti-HIV / Superinfecção / Infecções por HIV / HIV-1 / Imunidade Celular Limite: Humans Idioma: En Revista: Virology Ano de publicação: 2014 Tipo de documento: Article
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Anticorpos Anti-HIV / Superinfecção / Infecções por HIV / HIV-1 / Imunidade Celular Limite: Humans Idioma: En Revista: Virology Ano de publicação: 2014 Tipo de documento: Article