Survival characteristics of injected human cartilage slurry in a nude mouse model: a preliminary study.
Ear Nose Throat J
; 93(7): 269-72, 2014 Jul.
Article
em En
| MEDLINE
| ID: mdl-25025413
ABSTRACT
We conducted a study to examine the viability, host response, and volume retention characteristics of drilled human septal cartilage slurry when injected into an athymic nude mouse model. We injected 0.2 ml of the slurry into the hind limbs of 6 mice. The mice were sequentially sacrificed over a period of 180 days. Histologic reviews of the hind limbs were performed to determine the viability of injected chondrocytes, host response, and volume retention. Specimens were obtained and histomorphologic analysis was performed at 1, 30, 90, and 180 days after injection. We identified viable cartilage throughout the study. Cartilage injection was well tolerated, and minimal inflammatory reaction occurred without significant adverse effects. The injected bolus of cartilage was found to have progressively dispersed throughout the muscle over time. Our findings warrant further investigation with a larger cohort of nude mice or possibly human subjects.
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Bases de dados:
MEDLINE
Assunto principal:
Condrócitos
/
Cartilagens Nasais
/
Sobrevivência de Enxerto
Tipo de estudo:
Prognostic_studies
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Ear Nose Throat J
Ano de publicação:
2014
Tipo de documento:
Article
País de afiliação:
Estados Unidos