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Population pharmacokinetics of abacavir in pregnant women.
Fauchet, Floris; Treluyer, Jean-Marc; Préta, Laure-Helene; Valade, Elodie; Pannier, Emmanuelle; Urien, Saik; Hirt, Déborah.
Afiliação
  • Fauchet F; EA 08 Université Paris Descartes, Sorbonne Paris Cité, Paris, France Unité de Recherche Clinique, AP-HP, Hôpital Tarnier, Paris, France florisfauchet@gmail.com.
  • Treluyer JM; EA 08 Université Paris Descartes, Sorbonne Paris Cité, Paris, France Unité de Recherche Clinique, AP-HP, Hôpital Tarnier, Paris, France Service de Pharmacologie Clinique, AP-HP, Groupe Hospitalier Paris Centre, Paris, France CIC-0901 Inserm, Cochin-Necker, Paris, France.
  • Préta LH; EA 08 Université Paris Descartes, Sorbonne Paris Cité, Paris, France.
  • Valade E; EA 08 Université Paris Descartes, Sorbonne Paris Cité, Paris, France Unité de Recherche Clinique, AP-HP, Hôpital Tarnier, Paris, France.
  • Pannier E; Service de Gynécologie-Obstétrique, Maternité Port Royal, Groupe Hospitalier Paris Centre, Paris, France.
  • Urien S; EA 08 Université Paris Descartes, Sorbonne Paris Cité, Paris, France Unité de Recherche Clinique, AP-HP, Hôpital Tarnier, Paris, France CIC-0901 Inserm, Cochin-Necker, Paris, France.
  • Hirt D; EA 08 Université Paris Descartes, Sorbonne Paris Cité, Paris, France Unité de Recherche Clinique, AP-HP, Hôpital Tarnier, Paris, France Service de Pharmacologie Clinique, AP-HP, Groupe Hospitalier Paris Centre, Paris, France CIC-0901 Inserm, Cochin-Necker, Paris, France.
Antimicrob Agents Chemother ; 58(10): 6287-9, 2014 Oct.
Article em En | MEDLINE | ID: mdl-25070097
ABSTRACT
For the first time, a population approach was used to describe abacavir (ABC) pharmacokinetics in HIV-infected pregnant and nonpregnant women. A total of 266 samples from 150 women were obtained. No covariate effect (from age, body weight, pregnancy, or gestational age) on ABC pharmacokinetics was found. Thus, it seems unnecessary to adapt the ABC dosing regimen during pregnancy.
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Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Didesoxinucleosídeos / Fármacos Anti-HIV Limite: Female / Humans / Pregnancy Idioma: En Revista: Antimicrob Agents Chemother Ano de publicação: 2014 Tipo de documento: Article País de afiliação: França
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Didesoxinucleosídeos / Fármacos Anti-HIV Limite: Female / Humans / Pregnancy Idioma: En Revista: Antimicrob Agents Chemother Ano de publicação: 2014 Tipo de documento: Article País de afiliação: França