Hypercoagulability in cancer patients grouped by syndromes differentiated with the theory of abnormal hilit in traditional Uyghur medicine.

ABSTRACT

OBJECTIVE: To investigate the relationship in malignant-neoplasm patients of hypercoagulability between syndromes differentiated with the theory of abnormal hilit in traditional Uyghur medicine (TUM). METHODS: A total of 248 patients with malignant tumors were enrolled. Based on the theory of TUM they were divided into two groups abnormal Savda and abnormal Non-Savda (including abnormal Khan, abnormal Sepra and abnormal Belghem types); fifty healthy volunteers were selected as controls. Platelet (PLT), prothrombin time (PT), plasma fibrinogen (FIB), thrombin time (TT), activated partial thromboplastin time (aPTT) and D-Dimer (D-D) were measured in both groups. RESULTS: Compared with the control and abnormal Non-Savda groups, in the abnormal Savda group the PLT count increased (P < 0.05), the PT was lengthened (P < 0.01), and the FIB significantly increased (P < 0.01). D-Ds in the three groups were significantly different (P < 0.05). No significant difference was found in TT and aPTT values (P > 0.05). CONCLUSION: Hypercoagulability existed in patients with malignant tumors in the different types of TUM syndromes, especially in the abnormal Savda group; this was characterized by increased blood viscosity, platelet aggregation and thrombosis. D-D appears to be a significant predictor for the therapeutic effect of TUM in relation to malignant tumor therapies.