Amidation of esters with amino alcohols using organobase catalysis.
J Org Chem
; 79(19): 9347-54, 2014 Oct 03.
Article
em En
| MEDLINE
| ID: mdl-25226088
ABSTRACT
A catalytic protocol for the base-mediated amidation of unactivated esters with amino alcohol derivatives is reported. Investigations into mechanistic aspects of the process indicate that the reaction involves an initial transesterification, followed by an intramolecular rearrangement. The reaction is highly general in nature and can be extended to include the synthesis of oxazolidinone systems through use of dimethyl carbonate.
Texto completo:
1
Bases de dados:
MEDLINE
Assunto principal:
Oxazolidinonas
/
Amino Álcoois
Idioma:
En
Revista:
J Org Chem
Ano de publicação:
2014
Tipo de documento:
Article
País de afiliação:
Reino Unido