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Risk of congenital malformations for asthmatic pregnant women using a long-acting ß2-agonist and inhaled corticosteroid combination versus higher-dose inhaled corticosteroid monotherapy.
Eltonsy, Sherif; Forget, Amelie; Beauchesne, Marie-France; Blais, Lucie.
Afiliação
  • Eltonsy S; Faculty of Pharmacy, Université de Montréal, Montreal, Quebec, Canada; Hopital du Sacré-Cœur de Montréal, Montreal, Quebec, Canada.
  • Forget A; Faculty of Pharmacy, Université de Montréal, Montreal, Quebec, Canada; Hopital du Sacré-Cœur de Montréal, Montreal, Quebec, Canada.
  • Beauchesne MF; Faculty of Pharmacy, Université de Montréal, Montreal, Quebec, Canada; Département de Pharmacie, Centre Hospitalier Universitaire de Sherbrookes, Sherbrooke, Quebec, Canada.
  • Blais L; Faculty of Pharmacy, Université de Montréal, Montreal, Quebec, Canada; Hopital du Sacré-Cœur de Montréal, Montreal, Quebec, Canada. Electronic address: lucie.blais@umontreal.ca.
J Allergy Clin Immunol ; 135(1): 123-30, 2015 Jan.
Article em En | MEDLINE | ID: mdl-25226849
BACKGROUND: Current recommendations for managing persistent asthma during pregnancy when low-dose inhaled corticosteroids (ICSs) are insufficient include adding a long-acting ß2-agonist (LABA) or increasing the ICS dose. However, there are no data to help clinicians evaluate the safest regimen during pregnancy. OBJECTIVE: We sought to compare the risk of major congenital malformations in asthmatic women exposed to a LABA plus ICS combination and those exposed to ICS monotherapy at higher doses during the first trimester. METHODS: A cohort of asthmatic pregnant women exposed to ICSs during the first trimester who delivered between January 1990 and March 2009 was established. The primary outcome was major malformation recorded at birth or during the first year of life. Two subcohorts were established as follows: (1) users of a LABA plus low-dose ICS combination or users of a medium-dose ICS and (2) users of a LABA plus medium-dose ICS combination or users of a high-dose ICS. Generalized estimating equations were used to compare the risk of major malformations between the groups. RESULTS: In one subcohort there were 643 women who used a LABA plus low-dose ICS and 305 who used a medium-dose ICS; the other subcohort included 198 users of a LABA plus medium-dose ICS and 156 users of a high-dose ICS. The prevalence of major malformations was 6.9% and 7.2%, respectively. The adjusted odds ratio for major malformations was 1.1 (95% CI, 0.6-1.9) when a LABA plus low-dose ICS was used compared with a medium-dose ICS and 1.2 (95% CI, 0.5-2.7) when a LABA plus medium-dose ICS was used compared with a high-dose ICS. CONCLUSION: The risk of major malformations was similar with a LABA plus ICS combination and ICS monotherapy at higher doses, suggesting that both therapeutic options can be considered during pregnancy.
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Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Asma / Anormalidades Congênitas / Corticosteroides / Agonistas Adrenérgicos beta / Antiasmáticos Tipo de estudo: Etiology_studies / Guideline / Observational_studies / Prevalence_studies / Risk_factors_studies Limite: Adolescent / Adult / Female / Humans / Male / Newborn / Pregnancy País/Região como assunto: America do norte Idioma: En Revista: J Allergy Clin Immunol Ano de publicação: 2015 Tipo de documento: Article País de afiliação: Canadá

Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Asma / Anormalidades Congênitas / Corticosteroides / Agonistas Adrenérgicos beta / Antiasmáticos Tipo de estudo: Etiology_studies / Guideline / Observational_studies / Prevalence_studies / Risk_factors_studies Limite: Adolescent / Adult / Female / Humans / Male / Newborn / Pregnancy País/Região como assunto: America do norte Idioma: En Revista: J Allergy Clin Immunol Ano de publicação: 2015 Tipo de documento: Article País de afiliação: Canadá