A free-radical cascade methylation/cyclization of N-arylacrylamides and isocyanides with dicumyl peroxide.

ABSTRACT

A free-radical cascade methylation/cyclization of a wide range of N-arylacrylamides and isocyanides is demonstrated by using dicumyl peroxide as the methylating reagent, which provides a convenient and selective access to various methylated N-heterocycles such as oxindoles and phenanthridines.