Taste receptors in innate immunity.
Cell Mol Life Sci
; 72(2): 217-36, 2015 Jan.
Article
em En
| MEDLINE
| ID: mdl-25323130
ABSTRACT
Taste receptors were first identified on the tongue, where they initiate a signaling pathway that communicates information to the brain about the nutrient content or potential toxicity of ingested foods. However, recent research has shown that taste receptors are also expressed in a myriad of other tissues, from the airway and gastrointestinal epithelia to the pancreas and brain. The functions of many of these extraoral taste receptors remain unknown, but emerging evidence suggests that bitter and sweet taste receptors in the airway are important sentinels of innate immunity. This review discusses taste receptor signaling, focusing on the G-protein-coupled receptors that detect bitter, sweet, and savory tastes, followed by an overview of extraoral taste receptors and in-depth discussion of studies demonstrating the roles of taste receptors in airway innate immunity. Future research on extraoral taste receptors has significant potential for identification of novel immune mechanisms and insights into host-pathogen interactions.
Texto completo:
1
Bases de dados:
MEDLINE
Assunto principal:
Sistema Respiratório
/
Transdução de Sinais
/
Modelos Imunológicos
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Receptores Acoplados a Proteínas G
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Imunidade Inata
Tipo de estudo:
Qualitative_research
Limite:
Humans
Idioma:
En
Revista:
Cell Mol Life Sci
Assunto da revista:
BIOLOGIA MOLECULAR
Ano de publicação:
2015
Tipo de documento:
Article
País de afiliação:
Estados Unidos