Simvastatin potently induces calcium-dependent apoptosis of human leiomyoma cells.
J Biol Chem
; 289(51): 35075-86, 2014 Dec 19.
Article
em En
| MEDLINE
| ID: mdl-25359773
ABSTRACT
Statins are drugs commonly used for the treatment of high plasma cholesterol levels. Beyond these well known lipid-lowering properties, they possess broad-reaching effects in vivo, including antitumor effects. Statins inhibit the growth of multiple tumors. However, the mechanisms remain incompletely understood. Here we show that simvastatin inhibits the proliferation of human leiomyoma cells. This was associated with decreased mitogen-activated protein kinase signaling and multiple changes in cell cycle progression. Simvastatin potently stimulated leiomyoma cell apoptosis in a manner mechanistically dependent upon apoptotic calcium release from voltage-gated calcium channels. Therefore, simvastatin possesses antitumor effects that are dependent upon the apoptotic calcium release machinery.
Palavras-chave
Texto completo:
1
Bases de dados:
MEDLINE
Assunto principal:
Cálcio
/
Apoptose
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Sinvastatina
/
Proliferação de Células
Limite:
Humans
Idioma:
En
Revista:
J Biol Chem
Ano de publicação:
2014
Tipo de documento:
Article