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Utility of measuring (1,3)-ß-d-glucan in cerebrospinal fluid for diagnosis of fungal central nervous system infection.
Lyons, Jennifer L; Thakur, Kiran T; Lee, Rick; Watkins, Tonya; Pardo, Carlos A; Carson, Kathryn A; Markley, Barbara; Finkelman, Malcolm A; Marr, Kieren A; Roos, Karen L; Zhang, Sean X.
Afiliação
  • Lyons JL; Division of Neurological Infections, Department of Neurology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA.
  • Thakur KT; Department of Neurology, Johns Hopkins School of Medicine, Baltimore, Maryland, USA.
  • Lee R; Microbiology Laboratory, Johns Hopkins Hospital, Baltimore, Maryland, USA.
  • Watkins T; Division of Medical Microbiology, Department of Pathology, Johns Hopkins School of Medicine, Baltimore, Maryland, USA.
  • Pardo CA; Department of Neurology, Johns Hopkins School of Medicine, Baltimore, Maryland, USA.
  • Carson KA; Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.
  • Markley B; Associates of Cape Cod, Inc., Falmouth, Massachusetts, USA.
  • Finkelman MA; Associates of Cape Cod, Inc., Falmouth, Massachusetts, USA.
  • Marr KA; Division of Infectious Disease, Departments of Medicine and Oncology, Johns Hopkins School of Medicine, Baltimore, Maryland, USA.
  • Roos KL; Indiana University, Indianapolis, Indiana, USA.
  • Zhang SX; Microbiology Laboratory, Johns Hopkins Hospital, Baltimore, Maryland, USA Division of Medical Microbiology, Department of Pathology, Johns Hopkins School of Medicine, Baltimore, Maryland, USA szhang28@jhmi.edu.
J Clin Microbiol ; 53(1): 319-22, 2015 Jan.
Article em En | MEDLINE | ID: mdl-25378578
ABSTRACT
(1-3)-ß-d-Glucan (BDG) from cerebrospinal fluid (CSF) is a promising marker for diagnostic and prognostic aid of central nervous system (CNS) fungal infection, but its relationship to serum values has not been studied. Herein, we detected BDG from CSF at levels 2-fold lower than those in serum in patients without evidence of fungal disease but 25-fold higher than those in in serum in noncryptococcal CNS fungal infections. CSF BDG may be a useful biomarker in the evaluation of fungal CNS disease.
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Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Biomarcadores / Infecções Fúngicas do Sistema Nervoso Central / Beta-Glucanas Tipo de estudo: Diagnostic_studies / Prognostic_studies Limite: Adolescent / Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: J Clin Microbiol Ano de publicação: 2015 Tipo de documento: Article País de afiliação: Estados Unidos
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Biomarcadores / Infecções Fúngicas do Sistema Nervoso Central / Beta-Glucanas Tipo de estudo: Diagnostic_studies / Prognostic_studies Limite: Adolescent / Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: J Clin Microbiol Ano de publicação: 2015 Tipo de documento: Article País de afiliação: Estados Unidos