The Aspergillus nidulans metZ gene encodes a transcription factor involved in regulation of sulfur metabolism in this fungus and other Eurotiales.
Curr Genet
; 61(2): 115-25, 2015 May.
Article
em En
| MEDLINE
| ID: mdl-25391366
ABSTRACT
In Aspergillus nidulans, expression of sulfur metabolism genes is activated by the MetR transcription factor containing a basic region and leucine zipper domain (bZIP). Here we identified and characterized MetZ, a new transcriptional regulator in A. nidulans and other Eurotiales. It contains a bZIP domain similar to the corresponding region in MetR and this similarity suggests that MetZ could potentially complement the MetR deficiency. The metR and metZ genes are interrupted by unusually long introns. Transcription of metZ, unlike that of metR, is controlled by the sulfur metabolite repression system (SMR) dependent on the MetR protein. Overexpression of metZ from a MetR-independent promoter in a ΔmetR background activates transcription of genes encoding sulfate permease, homocysteine synthase and methionine permease, partially complementing the phenotype of the ΔmetR mutation. Thus, MetZ appears to be a second transcription factor involved in regulation of sulfur metabolism genes.
Texto completo:
1
Bases de dados:
MEDLINE
Assunto principal:
Aspergillus nidulans
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Enxofre
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Fatores de Transcrição
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Transcrição Gênica
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Proteínas Fúngicas
Tipo de estudo:
Prognostic_studies
Idioma:
En
Revista:
Curr Genet
Ano de publicação:
2015
Tipo de documento:
Article