Identification of novel hypomorphic and null mutations in Klf1 derived from a genetic screen for modifiers of &#945;-globin transgene variegation.

Sorolla, Anabel; Tallack, Michael R; Oey, Harald; Harten, Sarah K; Daxinger, Lucia Clemens-; Magor, Graham W; Combes, Alex N; Ilsley, Melissa; Whitelaw, Emma; Perkins, Andrew C

Identification of novel hypomorphic and null mutations in Klf1 derived from a genetic screen for modifiers of α-globin transgene variegation.

Sorolla, Anabel; Tallack, Michael R; Oey, Harald; Harten, Sarah K; Daxinger, Lucia Clemens-; Magor, Graham W; Combes, Alex N; Ilsley, Melissa; Whitelaw, Emma; Perkins, Andrew C.

Afiliação

Sorolla A; Epigenetics Laboratory, QIMR Berghofer Medical Research Institute, Herston, QLD 4006, Australia.
Tallack MR; Mater-UQ Research Institute, The University of Queensland, Translational Research Institute, Woolloongabba, QLD 4102, Australia; School of Medicine, The University of Queensland, St Lucia, QLD 4072, Australia.
Oey H; La Trobe Institute for Molecular Science, Department of Genetics, La Trobe University, Bundoora, VIC 3086, Australia.
Harten SK; Epigenetics Laboratory, QIMR Berghofer Medical Research Institute, Herston, QLD 4006, Australia.
Daxinger LC; Center for Human and Clinical Genetics, Leiden University Medical Center, Leiden, The Netherlands.
Magor GW; Mater-UQ Research Institute, The University of Queensland, Translational Research Institute, Woolloongabba, QLD 4102, Australia.
Combes AN; Epigenetics Laboratory, QIMR Berghofer Medical Research Institute, Herston, QLD 4006, Australia.
Ilsley M; Mater-UQ Research Institute, The University of Queensland, Translational Research Institute, Woolloongabba, QLD 4102, Australia.
Whitelaw E; Epigenetics Laboratory, QIMR Berghofer Medical Research Institute, Herston, QLD 4006, Australia; La Trobe Institute for Molecular Science, Department of Genetics, La Trobe University, Bundoora, VIC 3086, Australia. Electronic address: E.Whitelaw@latrobe.edu.au.
Perkins AC; Mater-UQ Research Institute, The University of Queensland, Translational Research Institute, Woolloongabba, QLD 4102, Australia; School of Medicine, The University of Queensland, St Lucia, QLD 4072, Australia; Department of Cancer Services, Princess Alexandra Hospital, Woolloongabba, QLD 4102, Austr

Genomics ; 105(2): 116-22, 2015 Feb.

Article em En | MEDLINE | ID: mdl-25451176

Assuntos

Efeitos da Posição Cromossômica; Fatores de Transcrição Kruppel-Like/genética; Mutação; alfa-Globinas/genética; Anemia/genética; Animais; Testes Genéticos/métodos; Camundongos; Camundongos Transgênicos/embriologia; Camundongos Transgênicos/genética; Esplenomegalia/genética; Dedos de Zinco/genética

Palavras-chave

EKLF; ENU mutagenesis; Epigenetics; Erythropoiesis; KLF1; Position effect variegation; Transcriptional regulation; Zinc-finger transcription factor; α-Globin

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Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Fatores de Transcrição Kruppel-Like / Alfa-Globinas / Efeitos da Posição Cromossômica / Mutação Tipo de estudo: Diagnostic_studies / Prognostic_studies Limite: Animals Idioma: En Revista: Genomics Assunto da revista: GENETICA Ano de publicação: 2015 Tipo de documento: Article País de afiliação: Austrália

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