Photodamage in deep tissue two-photon optical biopsy of human skin.
J Biophotonics
; 8(10): 816-25, 2015 Oct.
Article
em En
| MEDLINE
| ID: mdl-25524048
ABSTRACT
Photodamage, induced by femtosecond laser radiation, was studied in thick samples of human skin tissue (healthy skin and neoplastic lesions). Photobleaching, photoionization, and thermomechanical damage effects were characterized comparatively. The laser power dependence of the damage rates allowed to connect macroscopic effects to underlying molecular processes. Optical effects were correlated to histopathological changes. Tissue alterations were found only from thermomechanical cavitation and limited to superficial layers of the epidermis. From the depth-dependencies of all damage thresholds a depth-dependent power-compensation scheme was defined allowing for damage-free deep tissue optical biopsy. Damage-induced luminescence pattern for different excitation powers and a corresponding threshold analysis.
Palavras-chave
Texto completo:
1
Bases de dados:
MEDLINE
Assunto principal:
Pele
/
Fótons
/
Fenômenos Ópticos
Limite:
Humans
Idioma:
En
Revista:
J Biophotonics
Assunto da revista:
BIOFISICA
Ano de publicação:
2015
Tipo de documento:
Article
País de afiliação:
Itália