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Mosquito genomics. Highly evolvable malaria vectors: the genomes of 16 Anopheles mosquitoes.
Neafsey, Daniel E; Waterhouse, Robert M; Abai, Mohammad R; Aganezov, Sergey S; Alekseyev, Max A; Allen, James E; Amon, James; Arcà, Bruno; Arensburger, Peter; Artemov, Gleb; Assour, Lauren A; Basseri, Hamidreza; Berlin, Aaron; Birren, Bruce W; Blandin, Stephanie A; Brockman, Andrew I; Burkot, Thomas R; Burt, Austin; Chan, Clara S; Chauve, Cedric; Chiu, Joanna C; Christensen, Mikkel; Costantini, Carlo; Davidson, Victoria L M; Deligianni, Elena; Dottorini, Tania; Dritsou, Vicky; Gabriel, Stacey B; Guelbeogo, Wamdaogo M; Hall, Andrew B; Han, Mira V; Hlaing, Thaung; Hughes, Daniel S T; Jenkins, Adam M; Jiang, Xiaofang; Jungreis, Irwin; Kakani, Evdoxia G; Kamali, Maryam; Kemppainen, Petri; Kennedy, Ryan C; Kirmitzoglou, Ioannis K; Koekemoer, Lizette L; Laban, Njoroge; Langridge, Nicholas; Lawniczak, Mara K N; Lirakis, Manolis; Lobo, Neil F; Lowy, Ernesto; MacCallum, Robert M; Mao, Chunhong.
Afiliação
  • Neafsey DE; Genome Sequencing and Analysis Program, Broad Institute, 415 Main Street, Cambridge, MA 02142, USA. neafsey@broadinstitute.org nbesansk@nd.edu.
  • Waterhouse RM; Computer Science and Artificial Intelligence Laboratory, Massachusetts Institute of Technology, 32 Vassar Street, Cambridge, MA 02139, USA. The Broad Institute of Massachusetts Institute of Technology and Harvard, 415 Main Street, Cambridge, MA 02142, USA. Department of Genetic Medicine and Developm
  • Abai MR; Department of Medical Entomology and Vector Control, School of Public Health and Institute of Health Researches, Tehran University of Medical Sciences, Tehran, Iran.
  • Aganezov SS; George Washington University, Department of Mathematics and Computational Biology Institute, 45085 University Drive, Ashburn, VA 20147, USA.
  • Alekseyev MA; George Washington University, Department of Mathematics and Computational Biology Institute, 45085 University Drive, Ashburn, VA 20147, USA.
  • Allen JE; European Molecular Biology Laboratory, European Bioinformatics Institute, EMBL-EBI, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK.
  • Amon J; National Vector Borne Disease Control Programme, Ministry of Health, Tafea Province, Vanuatu.
  • Arcà B; Department of Public Health and Infectious Diseases, Division of Parasitology, Sapienza University of Rome, Piazzale Aldo Moro 5, 00185 Rome, Italy.
  • Arensburger P; Department of Biological Sciences, California State Polytechnic-Pomona, 3801 West Temple Avenue, Pomona, CA 91768, USA.
  • Artemov G; Tomsk State University, 36 Lenina Avenue, Tomsk, Russia.
  • Assour LA; Department of Computer Science and Engineering, Eck Institute for Global Health, 211B Cushing Hall, University of Notre Dame, Notre Dame, IN 46556, USA.
  • Basseri H; Department of Medical Entomology and Vector Control, School of Public Health and Institute of Health Researches, Tehran University of Medical Sciences, Tehran, Iran.
  • Berlin A; Genome Sequencing and Analysis Program, Broad Institute, 415 Main Street, Cambridge, MA 02142, USA.
  • Birren BW; Genome Sequencing and Analysis Program, Broad Institute, 415 Main Street, Cambridge, MA 02142, USA.
  • Blandin SA; Inserm, U963, F-67084 Strasbourg, France. CNRS, UPR9022, IBMC, F-67084 Strasbourg, France.
  • Brockman AI; Department of Life Sciences, Imperial College London, South Kensington Campus, London SW7 2AZ, UK.
  • Burkot TR; Faculty of Medicine, Health and Molecular Science, Australian Institute of Tropical Health Medicine, James Cook University, Cairns 4870, Australia.
  • Burt A; Department of Life Sciences, Imperial College London, Silwood Park Campus, Ascot SL5 7PY, UK.
  • Chan CS; Computer Science and Artificial Intelligence Laboratory, Massachusetts Institute of Technology, 32 Vassar Street, Cambridge, MA 02139, USA. The Broad Institute of Massachusetts Institute of Technology and Harvard, 415 Main Street, Cambridge, MA 02142, USA.
  • Chauve C; Department of Mathematics, Simon Fraser University, 8888 University Drive, Burnaby, BC V5A 1S6, Canada.
  • Chiu JC; Department of Entomology and Nematology, One Shields Avenue, University of California-Davis, Davis, CA 95616, USA.
  • Christensen M; European Molecular Biology Laboratory, European Bioinformatics Institute, EMBL-EBI, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK.
  • Costantini C; Institut de Recherche pour le Développement, Unités Mixtes de Recherche Maladies Infectieuses et Vecteurs Écologie, Génétique, Évolution et Contrôle, 911, Avenue Agropolis, BP 64501 Montpellier, France.
  • Davidson VL; Division of Biology, Kansas State University, 271 Chalmers Hall, Manhattan, KS 66506, USA.
  • Deligianni E; Institute of Molecular Biology and Biotechnology, Foundation for Research and Technology, Hellas, Nikolaou Plastira 100 GR-70013, Heraklion, Crete, Greece.
  • Dottorini T; Department of Life Sciences, Imperial College London, South Kensington Campus, London SW7 2AZ, UK.
  • Dritsou V; Centre of Functional Genomics, University of Perugia, Perugia, Italy.
  • Gabriel SB; Genomics Platform, Broad Institute, 415 Main Street, Cambridge, MA 02142, USA.
  • Guelbeogo WM; Centre National de Recherche et de Formation sur le Paludisme, Ouagadougou 01 BP 2208, Burkina Faso.
  • Hall AB; Program of Genetics, Bioinformatics, and Computational Biology, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061, USA.
  • Han MV; School of Life Sciences, University of Nevada, Las Vegas, NV 89154, USA.
  • Hlaing T; Department of Medical Research, No. 5 Ziwaka Road, Dagon Township, Yangon 11191, Myanmar.
  • Hughes DS; European Molecular Biology Laboratory, European Bioinformatics Institute, EMBL-EBI, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK. Baylor College of Medicine, 1 Baylor Plaza, Houston, TX 77030, USA.
  • Jenkins AM; Boston College, 140 Commonwealth Avenue, Chestnut Hill, MA 02467, USA.
  • Jiang X; Department of Biochemistry, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061, USA. Program of Genetics, Bioinformatics, and Computational Biology, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061, USA.
  • Jungreis I; Computer Science and Artificial Intelligence Laboratory, Massachusetts Institute of Technology, 32 Vassar Street, Cambridge, MA 02139, USA. The Broad Institute of Massachusetts Institute of Technology and Harvard, 415 Main Street, Cambridge, MA 02142, USA.
  • Kakani EG; Harvard School of Public Health, Department of Immunology and Infectious Diseases, Boston, MA 02115, USA. Dipartimento di Medicina Sperimentale e Scienze Biochimiche, Università degli Studi di Perugia, Perugia, Italy.
  • Kamali M; Department of Entomology, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061, USA.
  • Kemppainen P; Computational Evolutionary Biology Group, Faculty of Life Sciences, University of Manchester, Oxford Road, Manchester M13 9PT, UK.
  • Kennedy RC; Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, CA 94143, USA.
  • Kirmitzoglou IK; Department of Life Sciences, Imperial College London, South Kensington Campus, London SW7 2AZ, UK. Bioinformatics Research Laboratory, Department of Biological Sciences, New Campus, University of Cyprus, CY 1678 Nicosia, Cyprus.
  • Koekemoer LL; Wits Research Institute for Malaria, Faculty of Health Sciences, and Vector Control Reference Unit, National Institute for Communicable Diseases of the National Health Laboratory Service, Sandringham 2131, Johannesburg, South Africa.
  • Laban N; National Museums of Kenya, P.O. Box 40658-00100, Nairobi, Kenya.
  • Langridge N; European Molecular Biology Laboratory, European Bioinformatics Institute, EMBL-EBI, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK.
  • Lawniczak MK; Department of Life Sciences, Imperial College London, South Kensington Campus, London SW7 2AZ, UK.
  • Lirakis M; Department of Biology, University of Crete, 700 13 Heraklion, Greece.
  • Lobo NF; Eck Institute for Global Health and Department of Biological Sciences, University of Notre Dame, 317 Galvin Life Sciences Building, Notre Dame, IN 46556, USA.
  • Lowy E; European Molecular Biology Laboratory, European Bioinformatics Institute, EMBL-EBI, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, UK.
  • MacCallum RM; Department of Life Sciences, Imperial College London, South Kensington Campus, London SW7 2AZ, UK.
  • Mao C; Virginia Bioinformatics Institute, 1015 Life Science Circle, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061, USA.
Science ; 347(6217): 1258522, 2015 Jan 02.
Article em En | MEDLINE | ID: mdl-25554792
ABSTRACT
Variation in vectorial capacity for human malaria among Anopheles mosquito species is determined by many factors, including behavior, immunity, and life history. To investigate the genomic basis of vectorial capacity and explore new avenues for vector control, we sequenced the genomes of 16 anopheline mosquito species from diverse locations spanning ~100 million years of evolution. Comparative analyses show faster rates of gene gain and loss, elevated gene shuffling on the X chromosome, and more intron losses, relative to Drosophila. Some determinants of vectorial capacity, such as chemosensory genes, do not show elevated turnover but instead diversify through protein-sequence changes. This dynamism of anopheline genes and genomes may contribute to their flexible capacity to take advantage of new ecological niches, including adapting to humans as primary hosts.
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Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Evolução Molecular / Genoma de Inseto / Insetos Vetores / Malária / Anopheles Limite: Animals / Humans Idioma: En Revista: Science Ano de publicação: 2015 Tipo de documento: Article
Texto completo
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Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Evolução Molecular / Genoma de Inseto / Insetos Vetores / Malária / Anopheles Limite: Animals / Humans Idioma: En Revista: Science Ano de publicação: 2015 Tipo de documento: Article