Demyelination causes adult CNS progenitors to revert to an immature state and express immune cues that support their migration.
J Neurosci
; 35(1): 4-20, 2015 Jan 07.
Article
em En
| MEDLINE
| ID: mdl-25568099
ABSTRACT
The declining efficiency of myelin regeneration in individuals with multiple sclerosis has stimulated a search for ways by which it might be therapeutically enhanced. Here we have used gene expression profiling on purified murine oligodendrocyte progenitor cells (OPCs), the remyelinating cells of the adult CNS, to obtain a comprehensive picture of how they become activated after demyelination and how this enables them to contribute to remyelination. We find that adult OPCs have a transcriptome more similar to that of oligodendrocytes than to neonatal OPCs, but revert to a neonatal-like transcriptome when activated. Part of the activation response involves increased expression of two genes of the innate immune system, IL1ß and CCL2, which enhance the mobilization of OPCs. Our results add a new dimension to the role of the innate immune system in CNS regeneration, revealing how OPCs themselves contribute to the postinjury inflammatory milieu by producing cytokines that directly enhance their repopulation of areas of demyelination and hence their ability to contribute to remyelination.
Palavras-chave
Texto completo:
1
Bases de dados:
MEDLINE
Assunto principal:
Movimento Celular
/
Doenças Desmielinizantes
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Neurogênese
/
Células-Tronco Neurais
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Imunidade Inata
Tipo de estudo:
Etiology_studies
Limite:
Animals
Idioma:
En
Revista:
J Neurosci
Ano de publicação:
2015
Tipo de documento:
Article
País de afiliação:
França