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The discovery and optimization of aminooxadiazoles as potent Pim kinase inhibitors.
Wurz, Ryan P; Pettus, Liping H; Jackson, Claire; Wu, Bin; Wang, Hui-Ling; Herberich, Brad; Cee, Victor; Lanman, Brian A; Reed, Anthony B; Chavez, Frank; Nixey, Thomas; Laszlo, Jimmy; Wang, Paul; Nguyen, Yen; Sastri, Christine; Guerrero, Nadia; Winston, Jeff; Lipford, J Russell; Lee, Matthew R; Andrews, Kristin L; Mohr, Christopher; Xu, Yang; Zhou, Yihong; Reid, Darren L; Tasker, Andrew S.
Afiliação
  • Wurz RP; Department of Therapeutic Discovery, Amgen Inc., One Amgen Center Drive, Thousand Oaks, CA 91320-1799, USA. Electronic address: rwurz@amgen.com.
  • Pettus LH; Department of Therapeutic Discovery, Amgen Inc., One Amgen Center Drive, Thousand Oaks, CA 91320-1799, USA.
  • Jackson C; Department of Therapeutic Discovery, Amgen Inc., One Amgen Center Drive, Thousand Oaks, CA 91320-1799, USA.
  • Wu B; Department of Therapeutic Discovery, Amgen Inc., One Amgen Center Drive, Thousand Oaks, CA 91320-1799, USA.
  • Wang HL; Department of Therapeutic Discovery, Amgen Inc., One Amgen Center Drive, Thousand Oaks, CA 91320-1799, USA.
  • Herberich B; Department of Therapeutic Discovery, Amgen Inc., One Amgen Center Drive, Thousand Oaks, CA 91320-1799, USA.
  • Cee V; Department of Therapeutic Discovery, Amgen Inc., One Amgen Center Drive, Thousand Oaks, CA 91320-1799, USA.
  • Lanman BA; Department of Therapeutic Discovery, Amgen Inc., One Amgen Center Drive, Thousand Oaks, CA 91320-1799, USA.
  • Reed AB; Department of Therapeutic Discovery, Amgen Inc., One Amgen Center Drive, Thousand Oaks, CA 91320-1799, USA.
  • Chavez F; Department of Therapeutic Discovery, Amgen Inc., One Amgen Center Drive, Thousand Oaks, CA 91320-1799, USA.
  • Nixey T; Department of Therapeutic Discovery, Amgen Inc., One Amgen Center Drive, Thousand Oaks, CA 91320-1799, USA.
  • Laszlo J; Department of Discovery Technologies, Amgen Inc., One Amgen Center Drive, Thousand Oaks, CA 91320-1799, USA.
  • Wang P; Department of Molecular Structure and Characterization, Amgen Inc., One Amgen Center Drive, Thousand Oaks, CA 91320-1799, USA.
  • Nguyen Y; Department of Molecular Structure and Characterization, Amgen Inc., One Amgen Center Drive, Thousand Oaks, CA 91320-1799, USA.
  • Sastri C; Department of Oncology, Amgen Inc., One Amgen Center Drive, Thousand Oaks, CA 91320-1799, USA.
  • Guerrero N; Department of Oncology, Amgen Inc., One Amgen Center Drive, Thousand Oaks, CA 91320-1799, USA.
  • Winston J; Department of Oncology, Amgen Inc., One Amgen Center Drive, Thousand Oaks, CA 91320-1799, USA.
  • Lipford JR; Department of Oncology, Amgen Inc., One Amgen Center Drive, Thousand Oaks, CA 91320-1799, USA.
  • Lee MR; Department of Molecular Structure and Characterization, Amgen Inc., One Amgen Center Drive, Thousand Oaks, CA 91320-1799, USA.
  • Andrews KL; Department of Molecular Structure and Characterization, Amgen Inc., One Amgen Center Drive, Thousand Oaks, CA 91320-1799, USA.
  • Mohr C; Department of Molecular Structure and Characterization, Amgen Inc., One Amgen Center Drive, Thousand Oaks, CA 91320-1799, USA.
  • Xu Y; Department of Pharmacokinetics and Drug Metabolism, Amgen Inc., One Amgen Center Drive, Thousand Oaks, CA 91320-1799, USA.
  • Zhou Y; Department of Pharmacokinetics and Drug Metabolism, Amgen Inc., One Amgen Center Drive, Thousand Oaks, CA 91320-1799, USA.
  • Reid DL; Department of Pharmaceutics R&D, Amgen Inc., One Amgen Center Drive, Thousand Oaks, CA 91320-1799, USA.
  • Tasker AS; Department of Therapeutic Discovery, Amgen Inc., One Amgen Center Drive, Thousand Oaks, CA 91320-1799, USA.
Bioorg Med Chem Lett ; 25(4): 847-55, 2015 Feb 15.
Article em En | MEDLINE | ID: mdl-25599837
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Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Oxidiazóis / Inibidores de Proteínas Quinases / Proteínas Proto-Oncogênicas c-pim-1 Tipo de estudo: Prognostic_studies Idioma: En Revista: Bioorg Med Chem Lett Assunto da revista: BIOQUIMICA / QUIMICA Ano de publicação: 2015 Tipo de documento: Article
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Oxidiazóis / Inibidores de Proteínas Quinases / Proteínas Proto-Oncogênicas c-pim-1 Tipo de estudo: Prognostic_studies Idioma: En Revista: Bioorg Med Chem Lett Assunto da revista: BIOQUIMICA / QUIMICA Ano de publicação: 2015 Tipo de documento: Article