Synthesis of triphenylphosphonium phospholipid conjugates for the preparation of mitochondriotropic liposomes.
Methods Mol Biol
; 1265: 51-7, 2015.
Article
em En
| MEDLINE
| ID: mdl-25634266
ABSTRACT
Surface modification of liposomes with a ligand is facilitated by the conjugation of the ligand to a hydrophobic molecule that serves to anchor the ligand to the liposomal bilayer. We describe here a simple protocol to conjugate a triphenylphosphonium group to several commercially available functionalized phospholipids. The resulting triphenylphosphonium conjugated lipids can be used to prepare liposomes that preferentially associate with mitochondria when exposed to live mammalian cells in culture.
Texto completo:
1
Bases de dados:
MEDLINE
Assunto principal:
Compostos Organofosforados
/
Fosfolipídeos
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Lipossomos
/
Mitocôndrias
Idioma:
En
Revista:
Methods Mol Biol
Assunto da revista:
BIOLOGIA MOLECULAR
Ano de publicação:
2015
Tipo de documento:
Article