Astroglial glutamate transporter deficiency increases synaptic excitability and leads to pathological repetitive behaviors in mice.

Aida, Tomomi; Yoshida, Junichi; Nomura, Masatoshi; Tanimura, Asami; Iino, Yusuke; Soma, Miho; Bai, Ning; Ito, Yukiko; Cui, Wanpeng; Aizawa, Hidenori; Yanagisawa, Michiko; Nagai, Terumi; Takata, Norio; Tanaka, Kenji F; Takayanagi, Ryoichi; Kano, Masanobu; Götz, Magdalena; Hirase, Hajime; Tanaka, Kohichi

Aida, Tomomi; Yoshida, Junichi; Nomura, Masatoshi; Tanimura, Asami; Iino, Yusuke; Soma, Miho; Bai, Ning; Ito, Yukiko; Cui, Wanpeng; Aizawa, Hidenori; Yanagisawa, Michiko; Nagai, Terumi; Takata, Norio; Tanaka, Kenji F; Takayanagi, Ryoichi; Kano, Masanobu; Götz, Magdalena; Hirase, Hajime; Tanaka, Kohichi.

Afiliação

Aida T; Laboratory of Molecular Neuroscience, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan.
Yoshida J; Laboratory of Molecular Neuroscience, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan.
Nomura M; Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
Tanimura A; Department of Neurophysiology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan.
Iino Y; Laboratory of Molecular Neuroscience, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan.
Soma M; Laboratory of Molecular Neuroscience, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan.
Bai N; Laboratory of Molecular Neuroscience, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan.
Ito Y; Laboratory of Molecular Neuroscience, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan.
Cui W; Laboratory of Molecular Neuroscience, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan.
Aizawa H; Laboratory of Molecular Neuroscience, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan.
Yanagisawa M; Laboratory of Molecular Neuroscience, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan.
Nagai T; Laboratory for Neuron-Glia Circuitry, Brain Science Institute, RIKEN, Saitama, Japan.
Takata N; Laboratory for Neuron-Glia Circuitry, Brain Science Institute, RIKEN, Saitama, Japan.
Tanaka KF; Department of Neuropsychiatry, Keio University School of Medicine, Tokyo, Japan.
Takayanagi R; Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
Kano M; Department of Neurophysiology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan.
Götz M; Physiological Genomics, Institute of Physiology, Ludwig-Maximilians University Munich, Munich, Germany.
Hirase H; Department of Neuropsychiatry, Keio University School of Medicine, Tokyo, Japan.
Tanaka K; 1] Laboratory of Molecular Neuroscience, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan [2] JST, CREST, Saitama, Japan [3] The Center for Brain Integration Research, Tokyo Medical and Dental University, Tokyo, Japan.

Neuropsychopharmacology ; 40(7): 1569-79, 2015 Jun.

Article em En | MEDLINE | ID: mdl-25662838

Assuntos

Córtex Cerebral/patologia; Transtornos Traumáticos Cumulativos/genética; Transtornos Traumáticos Cumulativos/patologia; Transportador 1 de Aminoácido Excitatório/deficiência; Transportador 2 de Aminoácido Excitatório/deficiência; Sinapses/genética; Animais; Animais Recém-Nascidos; Ansiedade/genética; Transtornos Traumáticos Cumulativos/complicações; Transtornos Traumáticos Cumulativos/tratamento farmacológico; Modelos Animais de Doenças; Inibidores Enzimáticos/uso terapêutico; Transportador 1 de Aminoácido Excitatório/genética; Transportador 2 de Aminoácido Excitatório/genética; Potenciais Pós-Sinápticos Excitadores/genética; Feminino; Regulação da Expressão Gênica/genética; Hiperalgesia/genética; Masculino; Camundongos; Camundongos Transgênicos; Degeneração Neural/etiologia; Degeneração Neural/genética; Proteínas do Tecido Nervoso/metabolismo; Proteínas/genética; Convulsões/genética

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Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Sinapses / Transtornos Traumáticos Cumulativos / Córtex Cerebral / Transportador 1 de Aminoácido Excitatório / Transportador 2 de Aminoácido Excitatório Tipo de estudo: Etiology_studies / Prognostic_studies Limite: Animals Idioma: En Revista: Neuropsychopharmacology Assunto da revista: NEUROLOGIA / PSICOFARMACOLOGIA Ano de publicação: 2015 Tipo de documento: Article País de afiliação: Japão

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