Comparison of 25 and 50 microgram of misoprostol for induction of labour in nulliparous women with postdate pregnancy in Port Harcourt.
Niger J Clin Pract
; 18(2): 263-7, 2015.
Article
em En
| MEDLINE
| ID: mdl-25666004
ABSTRACT
BACKGROUND:
Induction of labor for postdate pregnancy using misoprostol is one of the most common interventions in pregnancy. However, the optimal dose of misoprostol is yet to be determined with previous reports utilizing different dosages.OBJECTIVE:
The main objective of this study was to compare the effectiveness and safety of 25 µg versus 50 µg of intravaginal misoprostol for induction of labor in nulliparous women with postdate pregnancy.METHODOLOGY:
This was a prospective study in which 88 nulliparous women with postdate pregnancy were randomly selected to receive either 25 µg or 50 µg of misoprostol for induction of labor. Student's t-test and Chi-square test were used to compare proportions.RESULTS:
There was no significant difference between the two groups with regard to the induction-vaginal delivery interval between the two doses. The proportion of women delivering vaginally with a single dose of misoprostol (11/40 vs. 23/43, P = 0.01) and vomiting were significantly greater in the 50 µg group. However, there was no significant difference between both groups in terms of the need for augmentation of labor, caesarean section, tachysystole and hyperstimulation syndrome.CONCLUSION:
Intravaginal administration of 25 µg of misoprostol appears to be as effective, but safer than 50 µg for induction of labor in nulliparous women with postdate pregnancy.
Texto completo:
1
Bases de dados:
MEDLINE
Assunto principal:
Ocitócicos
/
Gravidez Prolongada
/
Cesárea
/
Misoprostol
/
Trabalho de Parto Induzido
Tipo de estudo:
Clinical_trials
/
Observational_studies
Limite:
Adult
/
Female
/
Humans
/
Pregnancy
País/Região como assunto:
Africa
Idioma:
En
Revista:
Niger J Clin Pract
Assunto da revista:
MEDICINA
Ano de publicação:
2015
Tipo de documento:
Article