Cycling regimen induces spinal circuitry plasticity and improves leg muscle coordination in individuals with spinocerebellar ataxia.
Arch Phys Med Rehabil
; 96(6): 1006-13, 2015 Jun.
Article
em En
| MEDLINE
| ID: mdl-25668777
ABSTRACT
OBJECTIVES:
To compare the reciprocal control of agonist and antagonist muscles in individuals with and without spinocerebellar ataxia (SCA) and to evaluate the effect of a 4-week leg cycling regimen on functional coordination and reciprocal control of agonist and antagonist muscles in patients with SCA.DESIGN:
Randomized controlled trial with repeated measures.SETTING:
Research laboratory in a general hospital.PARTICIPANTS:
Individuals with SCA (n=20) and without SCA (n=20).INTERVENTIONS:
A single 15-minute session of leg cycling and a 4-week cycling regimen. MAIN OUTCOMEMEASURES:
Individuals with SCA (n=20) and without SCA (n=20) underwent disynaptic reciprocal inhibition and D1 inhibition tests of the soleus muscles before and after a single 15-minute cycling session. Individuals with SCA were randomly assigned to either participate in 4 weeks of cycling training (n=10) or to receive no training (n=10). The disynaptic reciprocal inhibition and D1 inhibition and International Cooperative Ataxia Rating Scale (ICARS) scores were evaluated in both groups after 4 weeks.RESULTS:
Individuals with SCA showed abnormally strong resting values of disynaptic reciprocal inhibition and D1 inhibition (P<.001) and impaired inhibition modulation capacity after a single 15-minute session of cycling (P<.001). The inhibition modulation capacity was restored (P<.001), and the ICARS scores improved significantly (pre 13.5±9.81, post 11.3±8.74; P=.046) after 4 weeks of cycling training.CONCLUSIONS:
A 4-week cycling regimen can normalize the modulation of reciprocal inhibition and functional performance in individuals with SCA. These findings are applicable to the coordination training of patients.Palavras-chave
Texto completo:
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Bases de dados:
MEDLINE
Assunto principal:
Ataxias Espinocerebelares
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Extremidade Inferior
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Terapia por Exercício
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Reflexo H
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Plasticidade Neuronal
Tipo de estudo:
Clinical_trials
Limite:
Adult
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Aged
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
Arch Phys Med Rehabil
Ano de publicação:
2015
Tipo de documento:
Article