Review article: cytomegalovirus and inflammatory bowel disease.
Aliment Pharmacol Ther
; 41(8): 725-33, 2015 Apr.
Article
em En
| MEDLINE
| ID: mdl-25684400
ABSTRACT
BACKGROUND:
The association between ulcerative colitis and cytomegalovirus (CMV) has been recognised for over 50 years; and the role of CMV in ulcerative colitis in general, and steroid resistance in particular, remains a topic of ongoing controversy. The outcome for patients with CMV reactivation appears worse than that for patients without reactivation, but it is not entirely clear whether CMV is a contributor or a bystander and if treatment with anti-virals alters the course of inflammatory bowel disease (IBD).AIM:
To review the role of CMV associated with IBD, including epidemiology, clinical features, diagnosis and management strategies.METHODS:
By reviewing literature available on CMV associated with IBD in adult patients. A PubMed literature search was performed using the following terms individually or in combination CMV colitis, cytomegalovirus colitis, IBD and CMV, CMV treatment.RESULTS:
Cytomegalovirus reactivation is common in patients with severe colitis, with a reported prevalence of 4.5-16.6%, and as high as 25% in patients requiring colectomy for severe colitis. The outcome for this group of patients appears worse than that for patients without reactivation; however, reported remission rates following treatment with anti-viral therapy are as high as 71-86%.CONCLUSIONS:
Evidence, although not conclusive, supports testing for CMV colonic disease in cases of moderate to severe colitis, by processing biopsies for haematoxylin and eosin staining with immunohistochemistry and/or, CMV DNA real-time polymerase chain reaction; and if present treating with ganciclovir.
Texto completo:
1
Bases de dados:
MEDLINE
Assunto principal:
Doenças Inflamatórias Intestinais
/
Infecções por Citomegalovirus
Tipo de estudo:
Prevalence_studies
/
Risk_factors_studies
Limite:
Humans
Idioma:
En
Revista:
Aliment Pharmacol Ther
Assunto da revista:
FARMACOLOGIA
/
GASTROENTEROLOGIA
/
TERAPIA POR MEDICAMENTOS
Ano de publicação:
2015
Tipo de documento:
Article
País de afiliação:
Reino Unido