Hypogonadism and ecdysteroid production in Loa loa and Mansonella perstans filariasis.
Acta Trop
; 46(4): 249-56, 1989 Jul.
Article
em En
| MEDLINE
| ID: mdl-2571252
ABSTRACT
Possible endocrinological repercussions of infection with Loa loa and Mansonella perstans filariae were studied in Gabonese subjects. Microfilaremic males were compared with amicrofilaremic controls. In the infected group 13/105 subjects (12%) presented only abnormally low serum levels of testosterone (less than 4 ng/ml), 25/105 (24%) only abnormally high serum levels of gonadotrophins, FSH (greater than 15 mIU/ml) and LH (greater than 20 mIU/ml), and 22/105 (21%) presented anomalies in both testosterone and gonadotrophin levels. One out of 68 control subjects had 3.6 ng/ml seric testosterone and all had normal levels of gonadotrophins. Ecdysteroids were detected (greater than 0.025 ng/ml) in the serum of 87/97 (90%) microfilaremic subjects (GM 0.123 ng/ml) compared to 12/64 (19%) controls (GM 0.030 ng/ml). Ecdysteroids were detected in the urine of all subjects, infected (GM 8.468 ng/ml) as well as control (GM 1.245 ng/ml). The hormonal perturbations were correlated with the levels of Loa loa microfilaremia but not with those of serum and urinary ecdysteroids. These results demonstrate that microfilaremic subjects often show endocrinal signs of hypogonadism and present appreciable levels of ecdysteroids in serum and urine. A direct role for parasitic ecdysteroids in hypogonadism remains to be demonstrated.
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Bases de dados:
MEDLINE
Assunto principal:
Loíase
/
Filariose
/
Hipogonadismo
/
Hormônios de Invertebrado
/
Mansonelose
Limite:
Adult
/
Animals
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Acta Trop
Ano de publicação:
1989
Tipo de documento:
Article
País de afiliação:
Gabão