An active role for basement membrane assembly and modification in tissue sculpting.
J Cell Sci
; 128(9): 1661-8, 2015 May 01.
Article
em En
| MEDLINE
| ID: mdl-25717004
ABSTRACT
Basement membranes are a dense, sheet-like form of extracellular matrix (ECM) that underlie epithelia and endothelia, and surround muscle, fat and Schwann cells. Basement membranes separate tissues and protect them from mechanical stress. Although traditionally thought of as a static support structure, a growing body of evidence suggests that dynamic basement membrane deposition and modification instructs coordinated cellular behaviors and acts mechanically to sculpt tissues. In this Commentary, we highlight recent studies that support the idea that far from being a passive matrix, basement membranes play formative roles in shaping tissues.
Texto completo:
1
Bases de dados:
MEDLINE
Assunto principal:
Especificidade de Órgãos
/
Membrana Basal
Limite:
Animals
/
Humans
Idioma:
En
Revista:
J Cell Sci
Ano de publicação:
2015
Tipo de documento:
Article
País de afiliação:
Estados Unidos