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Luteal phase defect is associated with impaired VEGF mRNA expression in the secretory phase endometrium.
Sadekova, Olga N; Nikitina, Liudmila A; Rashidov, Timur N; Voloschuk, Irina N; Samokhodskaya, Larisa M; Demidova, Elena M; Tkachuk, Vsevolod A.
Afiliação
  • Sadekova ON; Department of Biochemistry, Faculty of Fundamental Medicine, Moscow University, Moscow, Russia.
  • Nikitina LA; Department of Biochemistry, Faculty of Fundamental Medicine, Moscow University, Moscow, Russia. Electronic address: lunikit@gmail.com.
  • Rashidov TN; V.F. Snegirev Obstetrics and Gynaecology Clinic, I.M. Sechenov First Moscow State Medical University, Moscow, Russia.
  • Voloschuk IN; Department of Pathological Anatomy, I.M. Sechenov First Moscow State Medical University, Moscow, Russia.
  • Samokhodskaya LM; Department of Biochemistry, Faculty of Fundamental Medicine, Moscow University, Moscow, Russia.
  • Demidova EM; V.F. Snegirev Obstetrics and Gynaecology Clinic, I.M. Sechenov First Moscow State Medical University, Moscow, Russia.
  • Tkachuk VA; Department of Biochemistry, Faculty of Fundamental Medicine, Moscow University, Moscow, Russia.
Reprod Biol ; 15(1): 65-8, 2015 Mar.
Article em En | MEDLINE | ID: mdl-25726379
ABSTRACT
Endometrial morphology and expression of vascular endothelial growth factor (VEGF) was examined in the endometria of women with history of recurrent miscarriage (RM group) and of fertile women without history of gynecological diseases (control group). Luteal phase defect (LPD) was diagnosed in 42% cases in the RM group vs. 13% in controls. Endometrial VEGF mRNA expression was lower in LPD endometria compared to mature endometria. In conclusion, LPD in non-pregnant endometrium is associated with angiogenic abnormalities and may cause pregnancy complications.
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Texto completo: 1 Bases de dados: MEDLINE Assunto principal: RNA Mensageiro / Regulação da Expressão Gênica / Fator A de Crescimento do Endotélio Vascular / Endométrio / Fase Luteal Tipo de estudo: Risk_factors_studies Limite: Female / Humans / Pregnancy Idioma: En Revista: Reprod Biol Assunto da revista: MEDICINA REPRODUTIVA Ano de publicação: 2015 Tipo de documento: Article País de afiliação: Federação Russa
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Bases de dados: MEDLINE Assunto principal: RNA Mensageiro / Regulação da Expressão Gênica / Fator A de Crescimento do Endotélio Vascular / Endométrio / Fase Luteal Tipo de estudo: Risk_factors_studies Limite: Female / Humans / Pregnancy Idioma: En Revista: Reprod Biol Assunto da revista: MEDICINA REPRODUTIVA Ano de publicação: 2015 Tipo de documento: Article País de afiliação: Federação Russa