SUMO2 overexpression enhances the generation and function of interleukin-17-producing CD8⺠T cells in mice.
Cell Signal
; 27(6): 1246-52, 2015 Jun.
Article
em En
| MEDLINE
| ID: mdl-25762490
ABSTRACT
Small ubiquitin-like modifier (SUMO) 2 is a small protein that controls the activity and stability of other proteins by SUMOylation. In this study, T cell-specific SUMO2 overexpressing transgenic mice were generated to study the effect of SUMO2 on T lymphocytes. SUMO2 overexpression promoted differentiation of interleukin (IL)-17-producing CD8(+) T cells, and significantly suppressed the growth of EL4 tumor cells in vivo. Moreover, the tumor tissue from SUMO2-overexpressing mice had higher interferon (IFN)-γ and granzyme B mRNA levels. Although SUMO2 overexpression did not increase IFN-γ or granzyme B production in cytotoxic T lymphocytes, IL-12 treatment restored and increased IFN-γ secretion in IL-17-producing CD8(+) T cells. SUMO2 overexpression also increased gene expression of chemokines, CCL4, and CXCL10, which attract cytotoxic T lymphocytes to tumor tissues. Additionally, SUMO2-overexpressing T cells exhibited increased STAT3 phosphorylation, implying a SUMO2 target which up-regulates STAT3 activity governing IL-17A-producing CD8(+) T cell differentiation and antitumor immune responses.
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Texto completo:
1
Bases de dados:
MEDLINE
Assunto principal:
Linfócitos T CD8-Positivos
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Interleucina-17
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Proteínas Modificadoras Pequenas Relacionadas à Ubiquitina
Limite:
Animals
Idioma:
En
Revista:
Cell Signal
Ano de publicação:
2015
Tipo de documento:
Article