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Clinicopathological and virological characteristics of superficially invasive squamous-cell carcinoma of the anus.
Arana, R; Fléjou, J-F; Si-Mohamed, A; Bauer, P; Etienney, I.
Afiliação
  • Arana R; Department of Pathology, Hôpital Saint-Antoine, Hôpitaux Universitaires Paris Est, AP-HP, Paris, France.
  • Fléjou JF; Université Pierre et Marie Curie - Paris 6, Paris, France.
  • Si-Mohamed A; Department of Pathology, Hôpital Saint-Antoine, Hôpitaux Universitaires Paris Est, AP-HP, Paris, France.
  • Bauer P; Université Pierre et Marie Curie - Paris 6, Paris, France.
  • Etienney I; Department of Virology, Hôpital Européen Georges Pompidou, Hôpitaux Universitaires Paris Ouest, AP-HP, Paris, France.
Colorectal Dis ; 17(11): 965-72, 2015 Nov.
Article em En | MEDLINE | ID: mdl-25784158
ABSTRACT

AIM:

The clinicopathological and virological characteristics of anal superficially invasive squamous-cell carcinoma (SISCCA) were determined.

METHOD:

Seventeen patients with a completely excised stage T1N0M0 anal squamous-cell carcinoma (SCC) were included in the study. The tumours were divided into superficially invasive and invasive. Patients with anal high-grade squamous intraepithelial dysplasia, which corresponded to anal intraepithelial neoplasia (AIN) Grades 2 or 3, were used as a control group. Clinicopathological and virological characteristics were investigated. Overall survival and cancer recurrence-free survival were also assessed.

RESULTS:

Of the 17 patients, 12 (70.5%) were men. Ten (58.8%) were human immunodeficiency virus positive. Seven (41%) patients met the same diagnostic criteria as those recently proposed for anal SISCCA. According to the results obtained using the polymerase chain reaction, human papillomavirus (HPV) 16 was the most commonly detected (94%) type of HPV. Twelve (70.6%) patients with an inadequate surgical margin around the tumour received adjuvant radiotherapy, including the two (11.7%) tumours that locally recurred, one of which was an anal SISCCA. Superficially invasive anal cancers differed from the other T1N0M0 anal carcinomas according to the clinical presentation and the absence of lymph-vascular invasion (LVI). There were no differences in cancer recurrence-free and overall survival rates between the superficially invasive and invasive groups.

CONCLUSION:

Anal SISCCAs have a low index of clinical suspicion, are associated with an absence of LVI and are linked to high-risk HPV. Prospective studies are needed to define the clinical behaviour of these anal tumours and to determine their best therapeutic strategy.
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Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Canal Anal / Neoplasias do Ânus / Papillomaviridae / DNA Viral / Carcinoma de Células Escamosas / Infecções por Papillomavirus / Estadiamento de Neoplasias Tipo de estudo: Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Female / Humans / Male / Middle aged Idioma: En Revista: Colorectal Dis Assunto da revista: GASTROENTEROLOGIA Ano de publicação: 2015 Tipo de documento: Article País de afiliação: França

Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Canal Anal / Neoplasias do Ânus / Papillomaviridae / DNA Viral / Carcinoma de Células Escamosas / Infecções por Papillomavirus / Estadiamento de Neoplasias Tipo de estudo: Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Female / Humans / Male / Middle aged Idioma: En Revista: Colorectal Dis Assunto da revista: GASTROENTEROLOGIA Ano de publicação: 2015 Tipo de documento: Article País de afiliação: França