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Presenting phenotype of paediatric inflammatory bowel disease in Wessex, Southern England 2010-2013.
Ashton, J J; Coelho, T; Ennis, S; Batra, A; Afzal, N A; Beattie, R M.
Afiliação
  • Ashton JJ; Department of Paediatric Gastroenterology, University Hospital Southampton, Southampton, UK.
  • Coelho T; Department of Paediatric Gastroenterology, University Hospital Southampton, Southampton, UK.
  • Ennis S; Human Genetics and Genomic Medicine, University of Southampton, Duthie Building, University Hospital Southampton, Southampton, UK.
  • Batra A; Department of Paediatric Gastroenterology, University Hospital Southampton, Southampton, UK.
  • Afzal NA; Department of Paediatric Gastroenterology, University Hospital Southampton, Southampton, UK.
  • Beattie RM; Department of Paediatric Gastroenterology, University Hospital Southampton, Southampton, UK.
Acta Paediatr ; 104(8): 831-7, 2015 Aug.
Article em En | MEDLINE | ID: mdl-25847524
AIM: There has been at least a twofold increase in the incidence of paediatric inflammatory bowel disease (PIBD) over the last 20 years; we report the presenting features from 2010 to 2013 and compare with previous data. METHODS: All patients diagnosed with PIBD at University Hospitals Southampton from 2010 to 2013 were identified from an in-house database. Data were obtained from paper and electronic notes. Height, weight and BMI SDS are presented as median values (95% CI). RESULTS: One hundred and seventy-two patients were included (median age at diagnosis 13.5, 115 male); Crohn's disease (CD) - 107, UC - 50, inflammatory bowel disease unclassified (IBDU) - 15. The most common presenting features of CD were abdominal pain (86%), diarrhoea (78.5%) and weight loss (56.1%); 42.1% of patients had all three. In UC blood in stool (92%), diarrhoea (92%) and abdominal pain (88%) were the most common; all three in 76% of patients. CD presented with ileocolonic disease in 52.5%. UC presented with pancolitis in 64%. There was growth delay in CD: height -0.37 (-0.60 to -0.14); weight -1.09 (-1.35 to -0.83). Growth was maintained in UC: height 0.53 (0.19 to 0.87); weight 0.14 (-0.20 to 0.48). CONCLUSION: Paediatric inflammatory bowel disease phenotype remains as extensive despite increasing incidence. Although the classical phenotype is common, a reasonable proportion present with atypical features, normal growth and normal blood markers.
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Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Doenças Inflamatórias Intestinais Tipo de estudo: Diagnostic_studies / Prognostic_studies Limite: Adolescent / Female / Humans / Male País/Região como assunto: Europa Idioma: En Revista: Acta Paediatr Ano de publicação: 2015 Tipo de documento: Article

Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Doenças Inflamatórias Intestinais Tipo de estudo: Diagnostic_studies / Prognostic_studies Limite: Adolescent / Female / Humans / Male País/Região como assunto: Europa Idioma: En Revista: Acta Paediatr Ano de publicação: 2015 Tipo de documento: Article