A phase Ib multiple ascending dose study of the safety, tolerability, and central nervous system availability of AZD0530 (saracatinib) in Alzheimer's disease.

Nygaard, Haakon B; Wagner, Allison F; Bowen, Garrett S; Good, Susan P; MacAvoy, Martha G; Strittmatter, Kurt A; Kaufman, Adam C; Rosenberg, Brian J; Sekine-Konno, Tomoko; Varma, Pradeep; Chen, Kewei; Koleske, Anthony J; Reiman, Eric M; Strittmatter, Stephen M; van Dyck, Christopher H

Nygaard, Haakon B; Wagner, Allison F; Bowen, Garrett S; Good, Susan P; MacAvoy, Martha G; Strittmatter, Kurt A; Kaufman, Adam C; Rosenberg, Brian J; Sekine-Konno, Tomoko; Varma, Pradeep; Chen, Kewei; Koleske, Anthony J; Reiman, Eric M; Strittmatter, Stephen M; van Dyck, Christopher H.

Afiliação

Nygaard HB; Alzheimer's Disease Research Unit, Yale University School of Medicine, New Haven, Connecticut USA ; Department of Neurology, Yale University School of Medicine, New Haven, Connecticut USA ; Program in Cellular Neuroscience, Neurodegeneration and Repair (CNNR), Yale University School of Medicine, New
Wagner AF; Alzheimer's Disease Research Unit, Yale University School of Medicine, New Haven, Connecticut USA ; Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut USA.
Bowen GS; Alzheimer's Disease Research Unit, Yale University School of Medicine, New Haven, Connecticut USA ; Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut USA.
Good SP; Alzheimer's Disease Research Unit, Yale University School of Medicine, New Haven, Connecticut USA ; Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut USA.
MacAvoy MG; Alzheimer's Disease Research Unit, Yale University School of Medicine, New Haven, Connecticut USA ; Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut USA.
Strittmatter KA; Program in Cellular Neuroscience, Neurodegeneration and Repair (CNNR), Yale University School of Medicine, New Haven, Connecticut USA.
Kaufman AC; Program in Cellular Neuroscience, Neurodegeneration and Repair (CNNR), Yale University School of Medicine, New Haven, Connecticut USA.
Rosenberg BJ; Department of Molecular Biophysics and Biochemistry, Yale University School of Medicine, New Haven, Connecticut USA.
Sekine-Konno T; Department of Neurology, Yale University School of Medicine, New Haven, Connecticut USA.
Varma P; Department of Diagnostic Radiology, Yale University School of Medicine, New Haven, Connecticut USA.
Chen K; Banner Alzheimer's Institute, Phoenix, Arizona USA.
Koleske AJ; Program in Cellular Neuroscience, Neurodegeneration and Repair (CNNR), Yale University School of Medicine, New Haven, Connecticut USA ; Department of Molecular Biophysics and Biochemistry, Yale University School of Medicine, New Haven, Connecticut USA.
Reiman EM; Banner Alzheimer's Institute, Phoenix, Arizona USA.
Strittmatter SM; Department of Neurology, Yale University School of Medicine, New Haven, Connecticut USA ; Program in Cellular Neuroscience, Neurodegeneration and Repair (CNNR), Yale University School of Medicine, New Haven, Connecticut USA.
van Dyck CH; Alzheimer's Disease Research Unit, Yale University School of Medicine, New Haven, Connecticut USA ; Department of Neurology, Yale University School of Medicine, New Haven, Connecticut USA ; Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut USA.

Alzheimers Res Ther ; 7(1): 35, 2015.

Article em En | MEDLINE | ID: mdl-25874001

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Texto completo: 1 Bases de dados: MEDLINE Tipo de estudo: Clinical_trials / Prognostic_studies Idioma: En Revista: Alzheimers Res Ther Ano de publicação: 2015 Tipo de documento: Article

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