Changes in MMP-9 and TIMP-1 Concentrations in Cerebrospinal Fluid after 1 Week of Treatment of Childhood Bacterial Meningitis.

Roine, Irmeli; Pelkonen, Tuula; Lauhio, Anneli; Lappalainen, Maija; Cruzeiro, Manuel Leite; Bernardino, Luis; Tervahartiala, Taina; Sorsa, Timo; Peltola, Heikki

Roine, Irmeli; Pelkonen, Tuula; Lauhio, Anneli; Lappalainen, Maija; Cruzeiro, Manuel Leite; Bernardino, Luis; Tervahartiala, Taina; Sorsa, Timo; Peltola, Heikki.

Afiliação

Roine I; Faculty of Medicine, Universidad Diego Portales, Santiago, Chile irmeli.roine@gmail.com.
Pelkonen T; Hospital Pediátrico David Bernardino, Luanda, Angola Children's Hospital, Helsinki University Hospital and University of Helsinki, Helsinki, Finland.
Lauhio A; Infectious Diseases, Inflammation Center, Helsinki University Hospital and University of Helsinki, Helsinki, Finland.
Lappalainen M; Virology and Immunology, Laboratory Services (HUSLAB), Helsinki University Hospital, Helsinki, Finland.
Cruzeiro ML; Hospital Pediátrico David Bernardino, Luanda, Angola.
Bernardino L; Hospital Pediátrico David Bernardino, Luanda, Angola.
Tervahartiala T; Department of Oral and Maxillofacial Diseases, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
Sorsa T; Department of Oral and Maxillofacial Diseases, University of Helsinki and Helsinki University Hospital, Helsinki, Finland Division of Periodontology, Department of Dental Medicine, Karolinska Institutet, Huddinge, Sweden.
Peltola H; Children's Hospital, Helsinki University Hospital and University of Helsinki, Helsinki, Finland.

J Clin Microbiol ; 53(7): 2340-2, 2015 Jul.

Article em En | MEDLINE | ID: mdl-25903567

RESUMO

We explored the changes of the initially highly upgraded cerebrospinal fluid matrix metalloproteinase 9 (MMP-9) and tissue inhibitor of MMP 1 (TIMP-1) response during recovery of childhood bacterial meningitis and their association with outcome. The sizes of these changes varied substantially, but a steeper decrease in the MMP-9 and an increase of the TIMP-1 concentrations augured a better outcome.

Assuntos

Líquido Cefalorraquidiano/química; Metaloproteinase 9 da Matriz/líquido cefalorraquidiano; Meningites Bacterianas/tratamento farmacológico; Meningites Bacterianas/patologia; Inibidor Tecidual de Metaloproteinase-1/líquido cefalorraquidiano; Biomarcadores/líquido cefalorraquidiano; Pré-Escolar; Monitoramento de Medicamentos; Feminino; Humanos; Lactente; Estudos Longitudinais; Masculino; Resultado do Tratamento

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Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Líquido Cefalorraquidiano / Meningites Bacterianas / Inibidor Tecidual de Metaloproteinase-1 / Metaloproteinase 9 da Matriz Tipo de estudo: Observational_studies / Risk_factors_studies Limite: Child, preschool / Female / Humans / Infant / Male Idioma: En Revista: J Clin Microbiol Ano de publicação: 2015 Tipo de documento: Article País de afiliação: Chile

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