Akt1 phosphorylates Nicastrin to regulate its protein stability and activity.

Jo, Eun-Hye; Ahn, Ji-Seon; Mo, Jung-Soon; Yoon, Ji-Hye; Ann, Eun-Jung; Baek, Hyeong-Jin; Lee, Hye-Jin; Kim, Seol-Hee; Kim, Mi-Yeon; Park, Hee-Sae

Jo, Eun-Hye; Ahn, Ji-Seon; Mo, Jung-Soon; Yoon, Ji-Hye; Ann, Eun-Jung; Baek, Hyeong-Jin; Lee, Hye-Jin; Kim, Seol-Hee; Kim, Mi-Yeon; Park, Hee-Sae.

Afiliação

Jo EH; Hormone Research Center, School of Biological Sciences and Technology, Chonnam National University, Gwangju, Korea.
Ahn JS; Hormone Research Center, School of Biological Sciences and Technology, Chonnam National University, Gwangju, Korea.
Mo JS; Hormone Research Center, School of Biological Sciences and Technology, Chonnam National University, Gwangju, Korea.
Yoon JH; Hormone Research Center, School of Biological Sciences and Technology, Chonnam National University, Gwangju, Korea.
Ann EJ; Hormone Research Center, School of Biological Sciences and Technology, Chonnam National University, Gwangju, Korea.
Baek HJ; Hormone Research Center, School of Biological Sciences and Technology, Chonnam National University, Gwangju, Korea.
Lee HJ; Hormone Research Center, School of Biological Sciences and Technology, Chonnam National University, Gwangju, Korea.
Kim SH; Hormone Research Center, School of Biological Sciences and Technology, Chonnam National University, Gwangju, Korea.
Kim MY; Hormone Research Center, School of Biological Sciences and Technology, Chonnam National University, Gwangju, Korea.
Park HS; Hormone Research Center, School of Biological Sciences and Technology, Chonnam National University, Gwangju, Korea.

J Neurochem ; 134(5): 799-810, 2015 Sep.

Article em En | MEDLINE | ID: mdl-25996556

Assuntos

Secretases da Proteína Precursora do Amiloide/metabolismo; Glicoproteínas de Membrana/metabolismo; Proteínas Proto-Oncogênicas c-akt/fisiologia; Secretases da Proteína Precursora do Amiloide/genética; Precursor de Proteína beta-Amiloide/metabolismo; Técnicas de Silenciamento de Genes; Células HEK293; Células HeLa; Humanos; Lisossomos/metabolismo; Glicoproteínas de Membrana/genética; Modelos Biológicos; Fosforilação; Fosfosserina/metabolismo; Complexo de Endopeptidases do Proteassoma/metabolismo; Mapeamento de Interação de Proteínas; Processamento de Proteína Pós-Traducional; Estabilidade Proteica; Proteólise; Proteínas Proto-Oncogênicas c-akt/antagonistas & inibidores; Interferência de RNA; RNA Interferente Pequeno/farmacologia; Proteínas Recombinantes de Fusão/metabolismo

Palavras-chave

Akt1; Nicastrin; co-localization; lysosome; phosphorylation; proteasome

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Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Glicoproteínas de Membrana / Proteínas Proto-Oncogênicas c-akt / Secretases da Proteína Precursora do Amiloide Limite: Humans Idioma: En Revista: J Neurochem Ano de publicação: 2015 Tipo de documento: Article

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