Synthetic indole Mannich bases: Their ability to modulate in vitro cellular immunity.
Bioorg Chem
; 60: 118-22, 2015 Jun.
Article
em En
| MEDLINE
| ID: mdl-26000491
ABSTRACT
The synthetic indole Mannich bases 1-13 have been investigated for their ability to modulate immune responses measured in vitro. These activities were based on monitoring their affects on T-lymphocyte proliferation, reactive oxygen species (ROS), IL (interleukin)-2, IL-4, and nitric oxide production. Compound 5 was found to be the most potent immunomodulator in this context. Four of the synthesized compounds, 5, 11, 12, and 13, have significant potent inhibitory effects on T-cell proliferation, IL-4, and nitric oxide production. However, none of the thirteen indole compounds exerted any activity against ROS production.
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Texto completo:
1
Bases de dados:
MEDLINE
Assunto principal:
Imunidade Celular
/
Fatores Imunológicos
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Indóis
/
Bases de Mannich
Limite:
Adult
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Animals
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Humans
Idioma:
En
Revista:
Bioorg Chem
Ano de publicação:
2015
Tipo de documento:
Article