Modulation of Cytochrome P450 Activity by 18ß-Glycyrrhetic Acid and its Consequence on Buspirone Pharmacokinetics in Rats.

Kim, Sang-Bum; Cho, Hyun-Jong; Kim, Yeong Shik; Kim, Dae-Duk; Yoon, In-Soo

Kim, Sang-Bum; Cho, Hyun-Jong; Kim, Yeong Shik; Kim, Dae-Duk; Yoon, In-Soo.

Afiliação

Kim SB; College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University, Seoul, 151-742, Republic of Korea.
Cho HJ; College of Pharmacy, Kangwon National University, Chuncheon, 200-701, Republic of Korea.
Kim YS; Natural Products Research Institute, College of Pharmacy, Seoul National University, Seoul, 151-742, Republic of Korea.
Kim DD; College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University, Seoul, 151-742, Republic of Korea.
Yoon IS; College of Pharmacy and Natural Medicine Research Institute, Mokpo National University, Jeonnam, 534-729, Republic of Korea.

Phytother Res ; 29(8): 1188-94, 2015 Aug.

Article em En | MEDLINE | ID: mdl-26010440

Assuntos

Buspirona/farmacocinética; Citocromo P-450 CYP3A/metabolismo; Ácido Glicirretínico/análogos & derivados; Microssomos Hepáticos/efeitos dos fármacos; Administração Intravenosa; Administração Oral; Animais; Ácido Glicirretínico/farmacologia; Masculino; Microssomos Hepáticos/metabolismo; Ratos; Ratos Sprague-Dawley

Palavras-chave

18ß-glycyrrhetic acid; buspirone; cytochrome P450; hepatic metabolism; pharmacokinetics; rat

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Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Microssomos Hepáticos / Buspirona / Citocromo P-450 CYP3A / Ácido Glicirretínico Limite: Animals Idioma: En Revista: Phytother Res Assunto da revista: TERAPIAS COMPLEMENTARES Ano de publicação: 2015 Tipo de documento: Article

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