Evaluation of drug-induced QT interval prolongation in animal and human studies: a literature review of concordance.

Vargas, Hugo M; Bass, Alan S; Koerner, John; Matis-Mitchell, Sherri; Pugsley, Michael K; Skinner, Matthew; Burnham, Matthew; Bridgland-Taylor, Matthew; Pettit, Syril; Valentin, Jean-Pierre

Vargas, Hugo M; Bass, Alan S; Koerner, John; Matis-Mitchell, Sherri; Pugsley, Michael K; Skinner, Matthew; Burnham, Matthew; Bridgland-Taylor, Matthew; Pettit, Syril; Valentin, Jean-Pierre.

Afiliação

Vargas HM; Integrated Discovery and Safety Pharmacology, Amgen, Inc., Thousand Oaks, CA, USA.
Bass AS; Safety Assessment, Merck Research Laboratories, Boston, MA, USA.
Koerner J; Center for Drug Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, MD, USA.
Matis-Mitchell S; Discovery Information, AstraZeneca R&D, Wilmington, DE, USA.
Pugsley MK; Safety and Exploratory Pharmacology, Janssen R&D, Raritan, NJ, USA.
Skinner M; Safety Assessment, AstraZeneca R&D, Cheshire, UK.
Burnham M; Safety Assessment, AstraZeneca R&D, Cheshire, UK.
Bridgland-Taylor M; Safety Assessment, AstraZeneca R&D, Cheshire, UK.
Pettit S; Health and Environmental Sciences Institute, Washington, DC, USA.
Valentin JP; Safety Assessment, AstraZeneca R&D, Cheshire, UK.

Br J Pharmacol ; 172(16): 4002-11, 2015 Aug.

Article em En | MEDLINE | ID: mdl-26031452

Assuntos

Síndrome do QT Longo/induzido quimicamente; Animais; Avaliação Pré-Clínica de Medicamentos; Humanos; Sensibilidade e Especificidade

Texto completo

Adicionar na Minha BVS

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Bases de dados: MEDLINE Assunto principal: Síndrome do QT Longo Tipo de estudo: Diagnostic_studies / Guideline / Prognostic_studies Limite: Animals / Humans Idioma: En Revista: Br J Pharmacol Ano de publicação: 2015 Tipo de documento: Article País de afiliação: Estados Unidos

Texto completo

Adicionar na Minha BVS

Imprimir

XML

PubMed Links

Buscar no Google