Central effects of humanin on hepatic triglyceride secretion.
Am J Physiol Endocrinol Metab
; 309(3): E283-92, 2015 Aug 01.
Article
em En
| MEDLINE
| ID: mdl-26058861
ABSTRACT
Humanin (HN) is an endogenous mitochondria-associated peptide that has been shown to protect against various Alzheimer's disease-associated insults, myocardial ischemia-reperfusion injury, and reactive oxygen species-induced cell death. We have shown previously that HN improves whole body glucose homeostasis by improving insulin sensitivity and increasing glucose-stimulated insulin secretion (GSIS) from the ß-cells. Here, we report that intraperitoneal treatment with one of HN analogs, HNG, decreases body weight gain, visceral fat, and hepatic triglyceride (TG) accumulation in high-fat diet-fed mice. The decrease in hepatic TG accumulation is due to increased activity of hepatic microsomal triglyceride transfer protein (MTTP) and increased hepatic TG secretion. Both intravenous (iv) and intracerebroventricular (icv) infusion of HNG acutely increase TG secretion from the liver. Vagotomy blocks the effect on both iv and icv HNG on TG secretion, suggesting that the effects of HNG on hepatic TG flux are centrally mediated. Our data suggest that HN is a new player in central regulation of peripheral lipid metabolism.
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Texto completo:
1
Bases de dados:
MEDLINE
Assunto principal:
Triglicerídeos
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Peptídeos e Proteínas de Sinalização Intracelular
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Fígado
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Modelos Biológicos
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Obesidade
Tipo de estudo:
Etiology_studies
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Prognostic_studies
Idioma:
En
Revista:
Am J Physiol Endocrinol Metab
Assunto da revista:
ENDOCRINOLOGIA
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FISIOLOGIA
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METABOLISMO
Ano de publicação:
2015
Tipo de documento:
Article